Effect of long-term administration of berberine on scopolamine-induced amnesia in rats

被引：53

作者：

Peng, WH

Hsieh, MT

Wu, CR

机构：

[1] Inst. of Chinese Pharmaceutical Sci., China Medical College, Taichung, 91, Hsueh Shih Road

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 74卷 / 03期

关键词：

berberine; scopolamine; passive avoidance;

D O I：

10.1254/jjp.74.261

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of berberine (BER) on scopolamine (SCOP)-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that BER at the doses of 0.1 and 0.5 g/kg after 7-day or 14-day administration significantly improved SCOP-induced amnesia. The anti-amnesic effect of BER after 14-day administration on the SCOP-induced amnesia was significantly augmented by physostigmine or neostigmine, and completely reversed by scopolamine N-methylbromide. These results suggest that the antiamnesic effect of BER after 14-day administration may be related to the increase in the peripheral and central cholinergic neuronal system activity.

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收藏

页码：261 / 266

页数：6

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