The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

被引：1132

作者：

Barres, Ben A. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA

来源：

NEURON | 2008年 / 60卷 / 03期

关键词：

D O I：

10.1016/j.neuron.2008.10.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In this perspective, I review recent evidence that glial cells are critical participants in every major aspect of brain development, function, and disease. Far more active than once thought, glial cells powerfully control synapse formation, function, and blood flow. They secrete many substances whose roles are not understood, and they are central players in CNS injury and disease. I argue that until the roles of nonneuronal cells are more fully understood and considered, neurobiology as a whole will progress only slowly.

引用

收藏

页码：430 / 440

页数：11

相关论文

共 81 条

[1]

What is the role of astrocyte calcium in neurophysiology? [J].

Agulhon, Cendra ;

Petravicz, Jeremy ;

McMullen, Allison B. ;

Sweger, Elizabeth J. ;

Minton, Suzanne K. ;

Taves, Sarah R. ;

Casper, Kristen B. ;

Fiacco, Todd A. ;

McCarthy, Ken D. .

NEURON, 2008, 59 (06) :932-946

[2]

Tripartite synapses: glia, the unacknowledged partner [J].

Araque, A ;

Parpura, V ;

Sanzgiri, RP ;

Haydon, PG .

TRENDS IN NEUROSCIENCES, 1999, 22 (05) :208-215

[3]

TNFα promotes proliferation of oligodendrocyte progenitors and remyelination [J].

Arnett, HA ;

Mason, J ;

Marino, M ;

Suzuki, K ;

Matsushima, GK ;

Ting, JPY .

NATURE NEUROSCIENCE, 2001, 4 (11) :1116-1122

[4]

Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder [J].

Aston, C ;

Jiang, L ;

Sokolov, BP .

MOLECULAR PSYCHIATRY, 2005, 10 (03) :309-322

[5]

Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis [J].

Bailey-Bucktrout, Samantha L. ;

Caulkins, Sarah C. ;

Goings, Gwendolyn ;

Fischer, Jens A. A. ;

Dzionek, Andrzej ;

Miller, Stephen D. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (10) :6457-6461

[6]

TROPHIC INTERACTIONS BETWEEN ASTROGLIAL CELLS AND HIPPOCAMPAL-NEURONS IN CULTURE [J].

BANKER, GA .

SCIENCE, 1980, 209 (4458) :809-810

[7]

Axon branch removal at developing synapses by axosome shedding [J].

Bishop, DL ;

Misgeld, T ;

Walsh, MK ;

Gan, WB ;

Lichtman, JW .

NEURON, 2004, 44 (04) :651-661

[8]

BOROUJERDI A, 2008, PAIN IN PRESS, DOI DOI 10.1016/J.PAIN.2008.05.004

[9]

Immune signalling in neural development, synaptic plasticity and disease [J].

Boulanger, LM ;

Shatz, CJ .

NATURE REVIEWS NEUROSCIENCE, 2004, 5 (07) :521-531

[10]

Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system [J].

Brinkmann, Bastian G. ;

Agarwal, Amit ;

Sereda, Michael W. ;

Garratt, Alistair N. ;

Mueller, Thomas ;

Wende, Hagen ;

Stassart, Ruth M. ;

Nawaz, Schanila ;

Humml, Christian ;

Velanac, Viktorija ;

Radyushkin, Konstantin ;

Goebbels, Sandra ;

Fischer, Tobias M. ;

Franklin, Robin J. ;

Lai, Cary ;

Ehrenreich, Hannelore ;

Birchmeier, Carmen ;

Schwab, Markus H. ;

Nave, Klaus Armin .

NEURON, 2008, 59 (04) :581-595

← 1 2 3 4 5 6 7 8 9 →