Interleukin-1β is associated with depressive episode in major depression but not in bipolar disorder

被引:58
作者
Mota, Rosana [1 ]
Gazal, Marta [1 ]
Acosta, Bruna A. [1 ]
de Leon, Pamela B. [1 ]
Jansen, Karen [1 ]
Pinheiro, Ricardo T. [1 ]
Souza, Luciano D. [1 ]
Silva, Ricardo A. [1 ]
Oses, Jean P. [1 ]
Quevedo, Luciana [1 ]
Lara, Diogo R. [2 ]
Ghisleni, Gabriele [1 ]
Kaster, Manuella P. [1 ]
机构
[1] Univ Catolica Pelotas, Programa Posgrad Saude & Comportamento, BR-96015560 Pelotas, RS, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil
关键词
IL-1; beta; Major depression; Bipolar disorder; Current episode; INFLAMMATORY CYTOKINES; UNIPOLAR DEPRESSION; SERUM-LEVELS; MARKERS; IMMUNE; ALPHA; PATHOPHYSIOLOGY; INTERFERON; PREVALENCE; RECEPTORS;
D O I
10.1016/j.jpsychires.2013.08.020
中图分类号
R749 [精神病学];
学科分类号
100204 [神经病学];
摘要
Our work was sought to investigate possible changes in peripheral levels of interleukin-1 beta (IL-1 beta) according to the diagnosis of major depression (MD) and bipolar disorder (BD) and in different mood episodes. This is a cross-sectional nested in a population-based study comparing 240 young adults (80 controls, 80 MD and 80 BD), balanced for age and gender. Serum levels of IL-1 beta were significantly higher in MD when compared to control or BD subjects. In addition, when divided by current mood episode, MD subjects in current depression presented higher IL-1 beta levels than controls. No differences in IL-1 beta levels were found between different episodes of BD (euthymic, depressed, mania or mixed). Moreover, the use of psychiatric medication was very low in our sample and not associated with changes in IL-1 beta levels. In conclusion, increased peripheral IL-1 beta might be a useful marker associated with a depressive episode in the context of MD. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2011 / 2014
页数:4
相关论文
共 44 条
[1]
Cost of disorders of the brain in Europe [J].
Andlin-Sobocki, P ;
Jönsson, B ;
Wittchen, HU ;
Olesen, J .
EUROPEAN JOURNAL OF NEUROLOGY, 2005, 12 :1-+
[2]
Do many patients with depression suffer from bipolar disorder? [J].
Angst, J .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2006, 51 (01) :3-5
[3]
Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features [J].
Anisman, H ;
Ravindran, AV ;
Griffiths, J ;
Merali, Z .
MOLECULAR PSYCHIATRY, 1999, 4 (02) :182-188
[4]
Influence of continuous infusion of interleukin-1β on depression-related processes in mice:: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression [J].
Anisman, Hymie ;
Gibb, Julie ;
Hayley, Shawn .
PSYCHOPHARMACOLOGY, 2008, 199 (02) :231-244
[5]
Prevalence of bipolar II disorder in outpatient depression: A 203-case study in private practice [J].
Benazzi, F .
JOURNAL OF AFFECTIVE DISORDERS, 1997, 43 (02) :163-166
[6]
Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors [J].
Berk, M. ;
Kapczinski, F. ;
Andreazza, A. C. ;
Dean, O. M. ;
Giorlando, F. ;
Maes, M. ;
Yuecel, M. ;
Gama, C. S. ;
Dodd, S. ;
Dean, B. ;
Magalhaes, P. V. S. ;
Amminger, P. ;
McGorry, P. ;
Malhi, G. S. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2011, 35 (03) :804-817
[7]
Interleukin-1β and tumor necrosis factor-α in children with major depressive disorder or dysthymia [J].
Brambilla, F ;
Monteleone, P ;
Maj, M .
JOURNAL OF AFFECTIVE DISORDERS, 2004, 78 (03) :273-277
[8]
Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder [J].
Brietzke, Elisa ;
Stertz, Laura ;
Fernandes, Brisa Simoes ;
Kauer-Sant'Anna, Marcia ;
Mascarenhas, Marcello ;
Vargas, Andreia Escosteguy ;
Chies, Jose Artur ;
Kapczinski, Flavio .
JOURNAL OF AFFECTIVE DISORDERS, 2009, 116 (03) :214-217
[9]
Grand challenges in global mental health [J].
Collins, Pamela Y. ;
Patel, Vikram ;
Joestl, Sarah S. ;
March, Dana ;
Insel, Thomas R. ;
Daar, Abdallah S. .
NATURE, 2011, 475 (7354) :27-30
[10]
Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: Evidence for an overlap between manic/hypomanic and depressive symptoms [J].
Constant, A ;
Castera, L ;
Dantzer, R ;
Couzigou, P ;
de Ledinghen, V ;
Demotes-Mainard, J ;
Henry, C .
JOURNAL OF CLINICAL PSYCHIATRY, 2005, 66 (08) :1050-1057