Interleukin-1β is associated with depressive episode in major depression but not in bipolar disorder

被引：58

作者：

Mota, Rosana ^{[1
]}

Gazal, Marta ^{[1
]}

Acosta, Bruna A. ^{[1
]}

de Leon, Pamela B. ^{[1
]}

Jansen, Karen ^{[1
]}

Pinheiro, Ricardo T. ^{[1
]}

Souza, Luciano D. ^{[1
]}

Silva, Ricardo A. ^{[1
]}

Oses, Jean P. ^{[1
]}

Quevedo, Luciana ^{[1
]}

Lara, Diogo R. ^{[2
]}

Ghisleni, Gabriele ^{[1
]}

Kaster, Manuella P. ^{[1
]}

机构：

[1] Univ Catolica Pelotas, Programa Posgrad Saude & Comportamento, BR-96015560 Pelotas, RS, Brazil

[2] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2013年 / 47卷 / 12期

关键词：

IL-1; beta; Major depression; Bipolar disorder; Current episode; INFLAMMATORY CYTOKINES; UNIPOLAR DEPRESSION; SERUM-LEVELS; MARKERS; IMMUNE; ALPHA; PATHOPHYSIOLOGY; INTERFERON; PREVALENCE; RECEPTORS;

D O I：

10.1016/j.jpsychires.2013.08.020

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Our work was sought to investigate possible changes in peripheral levels of interleukin-1 beta (IL-1 beta) according to the diagnosis of major depression (MD) and bipolar disorder (BD) and in different mood episodes. This is a cross-sectional nested in a population-based study comparing 240 young adults (80 controls, 80 MD and 80 BD), balanced for age and gender. Serum levels of IL-1 beta were significantly higher in MD when compared to control or BD subjects. In addition, when divided by current mood episode, MD subjects in current depression presented higher IL-1 beta levels than controls. No differences in IL-1 beta levels were found between different episodes of BD (euthymic, depressed, mania or mixed). Moreover, the use of psychiatric medication was very low in our sample and not associated with changes in IL-1 beta levels. In conclusion, increased peripheral IL-1 beta might be a useful marker associated with a depressive episode in the context of MD. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2011 / 2014

页数：4

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