Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders

被引：1047

作者：

Dapretto, M ^{[1
]}

Davies, MS

Pfeifer, JH

Scott, AA

Sigman, M

Bookheimer, SY

Iacoboni, M

机构：

[1] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 01期

关键词：

D O I：

10.1038/nn1611

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

To examine mirror neuron abnormalities in autism, high-functioning children with autism and matched controls underwent fMRI while imitating and observing emotional expressions. Although both groups performed the tasks equally well, children with autism showed no mirror neuron activity in the inferior frontal gyrus (pars opercularis). Notably, activity in this area was inversely related to symptom severity in the social domain, suggesting that a dysfunctional 'mirror neuron system' may underlie the social deficits observed in autism.

引用

页码：28 / 30

页数：3

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