Protein folding and unfolding at atomic resolution

被引：451

作者：

Fersht, AR

Daggett, V

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Cambridge, MRC, Ctr Prot Engn, Cambridge CB2 1EW, England

[3] Univ Washington, Dept Med Chem, Seattle, WA 98195 USA

来源：

CELL | 2002年 / 108卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(02)00620-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Experiment and simulation are now conspiring to give atomic-level descriptions of protein folding relevant to folding, misfolding, trafficking, and degradation in the cell. We are on the threshold of predicting those protein folding events using simulation that has been carefully benchmarked by experiment.

引用

收藏

页码：573 / 582

页数：10

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