Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic

被引：124

作者：

Dokomajilar, C

Nsobya, SL

Greenhouse, B

Rosenthal, PJ

Dorsey, G

机构：

[1] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA USA

[2] Makerere Univ, Dept Med, Kampala, Uganda

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 05期

关键词：

D O I：

10.1128/AAC.50.5.1893-1895.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.

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页码：1893 / 1895

页数：3

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