Cilia and flagella revealed:: From flagellar assembly in Chlamydomonas to human obesity disorders

被引：116

作者：

Snell, WJ ^{[1
]}

Pan, JM ^{[1
]}

Wang, Q ^{[1
]}

机构：

[1] Univ Texas, SW Med Sch, Dept Cell Biol, Dallas, TX 75390 USA

来源：

CELL | 2004年 / 117卷 / 06期

关键词：

D O I：

10.1016/j.cell.2004.05.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent identification in Chlamydomonas of the intraflagellar transport machinery that assembles cilia and flagella has triggered a renaissance of interest in these organelles that transcends studies on their well-characterized ability to move. New studies on several fronts have revealed that the machinery for flagellar assembly/disassembly is regulated by homologs of mitotic proteins, that cilia play essential roles in sensory transduction, and that mutations in cilia/basal body proteins are responsible for cilia-related human disorders from polycystic kidney disease to a syndrome associated with obesity, hypertension, and diabetes.

引用

页码：693 / 697

页数：5

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