3-morpholinosydnonimine as instigator of a glibenclamide-sensitive reduction in the insulin secretory rate

被引：6

作者：

Antoine, MH ^{[1
]}

Ouedraogo, R ^{[1
]}

Hermann, M ^{[1
]}

Sergooris, J ^{[1
]}

Herchuelz, A ^{[1
]}

Lebrun, P ^{[1
]}

机构：

[1] FREE UNIV BRUSSELS,PHARMACOL LAB,SCH MED CP 617,B-1070 BRUSSELS,BELGIUM

来源：

BIOCHEMICAL PHARMACOLOGY | 1997年 / 53卷 / 08期

关键词：

SIN-1; glibenclamide; insulin release; pancreatic islets;

D O I：

10.1016/S0006-2952(96)00823-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The nitric oxide (NO) donor SIN-1 (3-morpholinosydnonimine) induced a concentration-dependent inhibition of the secretory response to glucose. The negative insulinotropic action of SIN-1 was attenuated by the hypoglycemic sulfonylurea glibenclamide. Moreover, the NO donor enhanced Rb-86 outflow from perfused islets and reduced the glucose-induced increase in Ca-45 outflow. The present data provide further evidence that NO donors impair the secretory response to glucose, at least in part, by activating the ATP-sensitive K+ channels. (C) 1997 Elsevier Science Inc.

引用

页码：1211 / 1213

页数：3

共 11 条

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