Extracellular vesicles in lung microenvironment and pathogenesis

被引：219

作者：

Fujita, Yu ^{[1
,2
,3
]}

Kosaka, Nobuyoshi ^{[1
,4
]}

Araya, Jun ^{[2
]}

Kuwano, Kazuyoshi ^{[2
]}

Ochiya, Takahiro ^{[1
]}

机构：

[1] Natl Canc Ctr, Div Mol & Cellular Med, Res Inst, Chuo Ku, Tokyo 1040045, Japan

[2] Jikei Univ, Sch Med, Dept Internal Med, Div Resp Dis,Minato Ku, Tokyo 1058471, Japan

[3] Univ Calif San Diego, Dept Pathol & Moores, Ctr Canc, La Jolla, CA 92093 USA

[4] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2015年 / 21卷 / 09期

基金：

日本学术振兴会;

关键词：

extracellular vesicle; exosome; microRNA; COPD; lung cancer; mesenchymal stem cell; CIRCULATING ENDOTHELIAL MICROPARTICLES; MESENCHYMAL STROMAL CELLS; EXOSOME SECRETION; AIRWAY EPITHELIUM; ADENOCARCINOMA CELLS; CIGARETTE-SMOKE; STEM-CELLS; CANCER; MICRORNAS; MICROVESICLES;

D O I：

10.1016/j.molmed.2015.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Increasing attention is being paid to the role of extracellular vesicles (EVs) in various lung diseases. EVs are released by a variety of cells, including respiratory cells and immune cells, and they encapsulate various molecules, such as proteins and microRNAs, as modulators of intercellular communication. Cancer cell-derived EVs play crucial roles in promoting tumor progression and modifying their microenvironment. By contrast, noncancerous cell-derived EVs demonstrate protective functions against injury, such as tissue recovery and repair, to maintain physiological homeostasis. Airway cells in contact with harmful substances may alter their EV composition and modify the balanced reciprocal interactions with surrounding mesenchymal cells. We summarize the novel findings of EV function in various lung diseases, primarily chronic obstructive pulmonary disease (COPD) and lung cancer.

引用

页码：533 / 542

页数：10

共 94 条

[1]

Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid [J].