Semagacestat's fall: where next for AD therapies?

被引:19
作者
Blennow, Kaj [1 ]
Zetterberg, Henrik [1 ]
Haass, Christian
机构
[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Clin Neurochem Lab, Molndal, Sweden
关键词
GAMMA-SECRETASE INHIBITOR; ALZHEIMERS-DISEASE; PRESENILIN-1; TRIAL; BACE1; AGE;
D O I
10.1038/nm.3365
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:1214 / 1215
页数:2
相关论文
共 16 条
[1]   Cerebrospinal fluid and plasma biomarkers in Alzheimer disease [J].
Blennow, Kaj ;
Hampel, Harald ;
Weiner, Michael ;
Zetterberg, Henrik .
NATURE REVIEWS NEUROLOGY, 2010, 6 (03) :131-144
[2]   Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles [J].
Cheret, Cyril ;
Willem, Michael ;
Fricker, Florence R. ;
Wende, Hagen ;
Wulf-Goldenberg, Annika ;
Tahirovic, Sabina ;
Nave, Klaus-Armin ;
Saftig, Paul ;
Haass, Christian ;
Garratt, Alistair N. ;
Bennett, David L. ;
Birchmeier, Carmen .
EMBO JOURNAL, 2013, 32 (14) :2015-2028
[3]   A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease [J].
Doody, Rachelle S. ;
Raman, Rema ;
Farlow, Martin ;
Iwatsubo, Takeshi ;
Vellas, Bruno ;
Joffe, Steven ;
Kieburtz, Karl ;
He, Feng ;
Sun, Xiaoying ;
Thomas, Ronald G. ;
Aisen, Paul S. ;
Siemers, Eric ;
Sethuraman, Gopalan ;
Mohs, Richard .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (04) :341-350
[4]   Phase 2 safety trial targeting amyloid β production with a γ-secretase inhibitor in Alzheimer disease [J].
Fleisher, Adam S. ;
Raman, Rema ;
Siemers, Eric R. ;
Becerra, Lida ;
Clark, Christopher M. ;
Dean, Robert A. ;
Farlow, Martin R. ;
Galvin, James E. ;
Peskind, Elaine R. ;
Quinn, Joseph F. ;
Sherzai, Abdullah ;
Sowell, Brooke ;
Aisen, Paul S. ;
Thal, Leon J. .
ARCHIVES OF NEUROLOGY, 2008, 65 (08) :1031-1038
[5]   Long-term effects of Aβ42 immunisation in Alzheimer's disease:: follow-up of a randomised, placebo-controlled phase I trial [J].
Holmes, Clive ;
Boche, Delphine ;
Wilkinson, David ;
Yadegarfar, Ghasem ;
Hopkins, Vivienne ;
Bayer, Anthony ;
Jones, Roy W. ;
Bullock, Roger ;
Love, Seth ;
Neal, James W. ;
Zotova, Elina ;
Nicoll, James A. R. .
LANCET, 2008, 372 (9634) :216-223
[6]   A mutation in APP protects against Alzheimer's disease and age-related cognitive decline [J].
Jonsson, Thorlakur ;
Atwal, Jasvinder K. ;
Steinberg, Stacy ;
Snaedal, Jon ;
Jonsson, Palmi V. ;
Bjornsson, Sigurbjorn ;
Stefansson, Hreinn ;
Sulem, Patrick ;
Gudbjartsson, Daniel ;
Maloney, Janice ;
Hoyte, Kwame ;
Gustafson, Amy ;
Liu, Yichin ;
Lu, Yanmei ;
Bhangale, Tushar ;
Graham, Robert R. ;
Huttenlocher, Johanna ;
Bjornsdottir, Gyda ;
Andreassen, Ole A. ;
Jonsson, Erik G. ;
Palotie, Aarno ;
Behrens, Timothy W. ;
Magnusson, Olafur T. ;
Kong, Augustine ;
Thorsteinsdottir, Unnur ;
Watts, Ryan J. ;
Stefansson, Kari .
NATURE, 2012, 488 (7409) :96-99
[7]   Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons [J].
Kuhn, Peer-Hendrik ;
Koroniak, Katarzyna ;
Hogl, Sebastian ;
Colombo, Alessio ;
Zeitschel, Ulrike ;
Willem, Michael ;
Volbracht, Christiane ;
Schepers, Ute ;
Imhof, Axel ;
Hoffmeister, Albrecht ;
Haass, Christian ;
Rossner, Steffen ;
Braese, Stefan ;
Lichtenthaler, Stefan F. .
EMBO JOURNAL, 2012, 31 (14) :3157-3168
[8]   FACILITATION OF LIN-12-MEDIATED SIGNALING BY SEL-12, A CAENORHABDITIS-ELEGANS S182 ALZHEIMERS-DISEASE GENE [J].
LEVITAN, D ;
GREENWALD, I .
NATURE, 1995, 377 (6547) :351-354
[9]   Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization [J].
Orgogozo, JM ;
Gilman, S ;
Dartigues, JF ;
Laurent, B ;
Puel, M ;
Kirby, LC ;
Jouanny, P ;
Dubois, B ;
Eisner, L ;
Flitman, S ;
Michel, BF ;
Boada, M ;
Frank, A ;
Hock, C .
NEUROLOGY, 2003, 61 (01) :46-54
[10]   A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease [J].
Portelius, Erik ;
Dean, Robert A. ;
Gustavsson, Mikael K. ;
Andreasson, Ulf ;
Zetterberg, Henrik ;
Siemers, Eric ;
Blennow, Kaj .
ALZHEIMERS RESEARCH & THERAPY, 2010, 2 (02)