Characterization of a human synovial cell antigen: VCAM-1 and inflammatory arthritis

被引：4

作者：

Carter, RA

O'Donnell, K

Sachthep, S

Cicuttini, FM

Boyd, AW

Wicks, IP ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Autoimmun & Transplantat Div, Reid Rheumatol Lab, Parkville, Vic 3050, Australia

[2] Royal Melbourne Hosp, Rheumatol Unit, Parkville, Vic 3050, Australia

[3] Monash Univ Sch Med, Prahran, Vic, Australia

[4] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2001年 / 79卷 / 05期

关键词：

rheumatoid arthritis; synovial cells; vascular cell adhesion molecule-1;

D O I：

10.1046/j.1440-1711.2001.01019.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The contribution of synovial cells to the pathogenesis of rheumatoid arthritis (RA) is only partly understood. Monoclonal antibody (mAb) 1D5 is one of very few mAb ever raised against RA synovial cells in order to study the biology of these cells. Studies on the expression pattern and structural features of the 1D5 Ag suggest that 1D5 recognizes human vascular cell adhesion molecule-1 (VCAM-1), which is an intercellular adhesion molecule. Vascular cell adhesion molecule-1 may be involved in a number of crucial intercellular interactions in RA.

引用

页码：419 / 428

页数：10

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