The Microbiome in Infectious Disease and Inflammation

被引：607

作者：

Honda, Kenya ^{[1
]}

Littman, Dan R. ^{[2
,3
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Immunol, Tokyo 1130033, Japan

[2] NYU, Sch Med, Skirball Inst, Mol Pathogenesis Program,Kimmel Ctr Biol & Med, New York, NY 10016 USA

[3] NYU, Sch Med, Howard Hughes Med Inst, Kimmel Ctr Biol & Med,Skirball Inst, New York, NY 10016 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 | 2012年 / 30卷

关键词：

intestinal microbiota; Th17; cells; Treg cells; innate lymphoid cells; segmented filamentous bacteria; Clostridium; REGULATORY T-CELLS; SEGMENTED FILAMENTOUS BACTERIA; ROR-GAMMA-T; GENOME-WIDE ASSOCIATION; PROTEIN-COUPLED RECEPTOR; INTESTINAL EPITHELIAL-CELLS; ARYL-HYDROCARBON RECEPTOR; INNATE IMMUNE RECOGNITION; CD103(+) DENDRITIC CELLS; TISSUE-INDUCER CELLS;

D O I：

10.1146/annurev-immunol-020711-074937

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The mammalian alimentary tract harbors hundreds of species of commensal microorganisms (microbiota) that intimately interact with the host and provide it with genetic, metabolic, and immunological attributes. Recent reports have indicated that the microbiota composition and its collective genomes (microbiome) are major factors in predetermining the type and robustness of mucosal immune responses. In this review, we discuss the recent advances in our understanding of host-microbiota interactions and their effect on the health and disease susceptibility of the host.

引用

页码：759 / 795

页数：37

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