Reversibility of prostatic intraepithelial neoplasia: Implications for chemoprevention

被引：19

作者：

Bostwick, DG ^{[1
]}

Neumann, R ^{[1
]}

Qian, JQ ^{[1
]}

Cheng, L ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Rochester, MN 55905 USA

来源：

EUROPEAN UROLOGY | 1999年 / 35卷 / 5-6期

关键词：

chemoprevention; prostatic intraepithelial neoplasia; prostate neoplasms; prostatic carcinoma; androgen deprivation therapy; hormonal therapy; radiation therapy;

D O I：

10.1159/000019885

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

High-grade prostatic intraepithelial neoplasia is the most likely precursor of prostatic adenocarcinoma, according to virtually all available evidence. It has a high predictive value as a marker for adenocarcinoma, and its identification in biopsy specimens of the prostate warrants further search for concurrent invasive carcinoma. Androgen deprivation therapy and radiation therapy decrease its prevalence and extent, suggesting a role in chemoprevention.

引用

页码：492 / 495

页数：4

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