The Parkinson's disease-related genes act in mitochondrial homeostasis

被引：58

作者：

Sai, Yan ^{[1
]}

Zou, Zhongmin ^{[1
]}

Peng, Kaige ^{[1
]}

Dong, Zhaojun ^{[1
]}

机构：

[1] Third Mil Med Univ, Inst Toxicol, Chongqing 400038, Peoples R China

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2012年 / 36卷 / 09期

关键词：

Mitochondrial homeostasis; Parkinson's disease; Alpha-synuclein; Parkin; DJ-1; PINK1; LRRK2; HUMAN ALPHA-SYNUCLEIN; PINK1/PARKIN PATHWAY; OXIDATIVE STRESS; COMPLEX-I; DOPAMINERGIC-NEURONS; PROTEIN DJ-1; LEWY BODIES; PINK1; DYSFUNCTION; MUTATIONS;

D O I：

10.1016/j.neubiorev.2012.06.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Neurons are metabolically active cells with high energy demands. Thus, neurons are particularly reliant on mitochondrial function, especially on the homeostasis properties of mitochondria. This is reflected by the observation that mitochondrial abnormalities have been well recognized to contribute to neurodegenerative diseases, like Parkinson's disease (PD). Mitochondria are highly complex and dynamic organelles continuously undergoing different alterations. The dynamic property of mitochondria is named as mitochondrial homeostasis. Imbalance of mitochondrial homeostasis is associated with neurodegenerative disease, such as Parkinson's diseases. Recently, the related genes of PD-familial, such as alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, are observed to be associated with mitochondria, and capable of modulating normal mitochondrial integrity and functions under certain conditions. Therefore, in this review, we will focus on the action of PD-related genes in mitochondrial homeostasis. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

引用

页码：2034 / 2043

页数：10

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