[Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat

被引：20

作者：

Chen, Y ^{[1
]}

Chang, M ^{[1
]}

Wang, ZZ ^{[1
]}

Chen, LX ^{[1
]}

Yang, Q ^{[1
]}

Qi, YM ^{[1
]}

Wang, R ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Life Sci, Dept Biochem & Mol Biol, Lanzhou 730000, Peoples R China

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2002年 / 80卷 / 01期

关键词：

nociceptin; Nphe(1)]nociceptin(1-13)-NH2; morphine; mean arterial pressure; heart rate; hindquarters vascular bed resistance;

D O I：

10.1139/Y02-003

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The purpose of this study was to investigate the effects of [Nphe(1)]nociceptin(1-13)-NH2 on nociceptin-induced decreases in mean arterial pressure (MAP), heart rate (HR), and hindquarters vascular bed resistance (HVBR) of the anesthetized rat. The results showed that i.c.v. or i.v. [Nphe(1)]nociceptin(1-13)-NH2 (1.5-12 nmol/kg and 5-120 nmol/kg, respectively) could antagonize the depressor effects of i.c.v. or i.v. nociceptin (3 and 30 nmol/kg, respectively) on MAP and HR. Furthermore, [Nphe(1)]nociceptin(1-13)-NH2 (5-120 nmol/kg) could reverse nociceptin (30 nmol/kg)-induced decrease of HVBR. However, [Nphe(1)]nociceptin(1-13)-NH2 had no significant effects on similar effects induced by morphine. Our results suggest that [Nphe(1)]nociceptin(1-13)-NH2 acts as a selective antagonist of the nociceptin receptor in the cardiovascular system of the rat.

引用

页码：31 / 35

页数：5

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