Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

被引：322

作者：

Bessac, Bret F. ^{[1
]}

Jordt, Sven-Eric ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA

来源：

PHYSIOLOGY | 2008年 / 23卷 / 06期

关键词：

D O I：

10.1152/physiol.00026.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species, and noxious constituents of smoke and smog, initiating irritation and airway reflex responses. Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome.

引用

页码：360 / 370

页数：11

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