Hidden Killers: Human Fungal Infections

被引：3172

作者：

Brown, Gordon D. ^{[1
]}

Denning, David W. ^{[2
]}

Gow, Neil A. R. ^{[1
]}

Levitz, Stuart M. ^{[3
]}

Netea, Mihai G. ^{[4
,5
]}

White, Theodore C. ^{[6
]}

机构：

[1] Univ Aberdeen, Inst Med Sci, Aberdeen Fungal Grp, Aberdeen AB25 2ZD, Scotland

[2] Univ S Manchester Hosp, Natl Aspergillosis Ctr Educ & Res Ctr, Manchester M23 9LT, Lancs, England

[3] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

[4] Radboud Univ Nijmegen, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Nijmegen Inst Infect Inflammat & Immun, NL-6500 HB Nijmegen, Netherlands

[6] Univ Missouri Kansas City, Sch Biol Sci, Kansas City, MO 64110 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 165期

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

BLOOD-STREAM INFECTIONS; ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; PULMONARY ASPERGILLOSIS; SEVERE ASTHMA; PNEUMOCYSTIS-JIROVECII; CRYPTOCOCCUS-GATTII; VACCINE DEVELOPMENT; STAT1; MUTATIONS; GLOBAL BURDEN; RISK-FACTORS;

D O I：

10.1126/scitranslmed.3004404

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although fungal infections contribute substantially to human morbidity and mortality, the impact of these diseases on human health is not widely appreciated. Moreover, despite the urgent need for efficient diagnostic tests and safe and effective new drugs and vaccines, research into the pathophysiology of human fungal infections lags behind that of diseases caused by other pathogens. In this Review, we highlight the importance of fungi as human pathogens and discuss the challenges we face in combating the devastating invasive infections caused by these microorganisms, in particular in immunocompromised individuals.

引用

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