The effect of faecal enema on five microflora-associated characteristics in patients with antibiotic-associated diarrhoea

被引:58
作者
Gustafsson, A
Berstad, A
Lund-Tonnesen, S
Midtvedt, T
Norin, E
机构
[1] Karolinska Inst, Dept Cell & Mol Biol, Lab Med Microbial Ecol, SE-17177 Stockholm, Sweden
[2] Haukeland Hosp, Dept Med, N-5021 Bergen, Norway
关键词
antibiotic-associated diarrhoea; beta-aspartylglycine; coprostanol; faecal enema; microflora; mucin; tryptic activity; urobilinogen;
D O I
10.1080/003655299750026038
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Patients with antibiotic-associated diarrhoea (AAD) show significant disturbances in short-chain fatty acid pattern. In the present study five more microflora-associated characteristics (MACs) were investigated before and after administration of an enema containing faecal microflora from a healthy person on a Western diet. Methods: The functions of the microflora were determined with gas chromatography, electrophoresis, and spectrophotometry. Results: The conversion of cholesterol to coprostanol and the concentration of urobilinogen and trypsin were significantly reduced in comparison with healthy persons. The pattern of mucin was altered, but beta-aspartylglycine remained the same as in healthy persons. Enema treatment influenced these functions to different extents. Conclusion: Most MACs were significantly disturbed in patients with AAD. Administration of a human faecal enema modified these changes and relieved diarrhoea, usually within 4 days.
引用
收藏
页码:580 / 586
页数:7
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