Development of porous spherical hydroxyapatite granules: application towards protein delivery

被引：184

作者：

Paul, W ^{[1
]}

Sharma, CP ^{[1
]}

机构：

[1] Sree Chitra Tirunal Inst Med Sci & Technol, Biomed Technol Wing, Div Biosurface Technol, Trivandrum 695012, Kerala, India

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 1999年 / 10卷 / 07期

关键词：

D O I：

10.1023/A:1008918412198

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new method for the preparation of porous spherical hydroxyapatite granules is reported. It may be clinically applied towards orthopaedic or maxillofacial surgery as fillers or packing materials, and as biological chromatography supports. Its application towards delivery of macromolecules or protein drugs is discussed utilizing human serum albumin (HSA) as a model protein. (C) 1999 Kluwer Academic Publishers.

引用

页码：383 / 388

页数：6

共 31 条

[1]

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[2]

Amador E., 1977, CLIN CHEM, V18, P60

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