A structural analog of the protosterol cation is not a strong inhibitor of sterol biosynthesis

被引：18

作者：

Corey, EJ

Daley, DC

Cheng, HM

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 19期

关键词：

D O I：

10.1016/0040-4039(96)00577-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The relatively modest potency of inhibition of lanosterol synthase by the tetracyclic ammonium ion 10, a structural analog of the protosterol cation 4, IC50 = 22 mu M, indicates that the protosterol cation is not strongly bound by the enzyme. (C) 1996 Elsevier Science Ltd.

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页码：3287 / 3290

页数：4

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[10]

COREY EJ, 1996, TETRAHEDRON LETT, V37