A Canadian Working Group report on fecal microbial therapy: Microbial ecosystems therapeutics

被引：43

作者：

Allen-Vercoe, Emma ^{[3
]}

Reid, Gregor ^{[2
,4
]}

Viner, Norman ^{[5
]}

Gloor, Gregory B. ^{[2
,4
]}

Hota, Susy ^{[7
]}

Kim, Peter ^{[3
]}

Lee, Christine ^{[6
]}

O'Doherty, Kieran C. ^{[3
]}

Vanner, Stephen J.

Weese, J. Scott ^{[3
]}

Petrof, Elaine O. ^{[1
]}

机构：

[1] Queens Univ, Gastrointestinal Dis Res Unit, Dept Med Infect Dis, Kingston, ON K7L 2V7, Canada

[2] Univ Western Ontario, London, ON N6A 3K7, Canada

[3] Univ Guelph, Guelph, ON N1G 2W1, Canada

[4] Lawson Hlth Res Inst, London, ON, Canada

[5] Hlth Canada, Ottawa, ON K1A 0L2, Canada

[6] McMaster Univ, Hamilton, ON, Canada

[7] Univ Toronto, Toronto, ON, Canada

来源：

CANADIAN JOURNAL OF GASTROENTEROLOGY | 2012年 / 26卷 / 07期

关键词：

Clostridium difficile; Fecal microbial therapy; Microbiome; CLOSTRIDIUM-DIFFICILE-INFECTION; DIARRHEA; BACTERIOTHERAPY; TRANSPLANTATION; RIBOTYPE-078; HUMANS;

D O I：

10.1155/2012/213828

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A working group from across Canada comprised of clinician and basic scientists, epidemiologists, ethicists, Health Canada regulatory authorities and representatives of major funding agencies (Canadian Institutes of Health Research and the Crohn's and Colitis Foundation of Canada) met to review the current experience with fecal microbial therapy and to identify the key areas of study required to move this field forward. The report highlights the promise of fecal microbial therapy and related synthetic stool therapy (together called 'microbial ecosystems therapeutics') for the treatment of Clostridium difficile colitis and, possibly, other disorders. It identifies pressing clinical issues that need to be addressed as well as social, ethical and regulatory barriers to the use of these important therapies.

引用

页码：457 / 462

页数：6

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