Surgical treatment of severe autistic regression in childhood epilepsy

被引:66
作者
Neville, BGR [1 ]
Harkness, WFJ [1 ]
Cross, JH [1 ]
Cass, HC [1 ]
Burch, VC [1 ]
Lees, JA [1 ]
Taylor, DC [1 ]
机构
[1] GREAT ORMOND ST HOSP CHILDREN NHS TRUST,LONDON WC1N 3JH,ENGLAND
关键词
D O I
10.1016/S0887-8994(96)00297-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We report 2 children with partial epilepsy who manifested social and language regression and partial recovery after surgical treatment. One child had seizures since the first 2 weeks of life, caused by a right temporal dysembryoplastic neuroepithelial tumor and regression in the latter part of the first year; seizures were relieved and some functions were recovered after temporal lobe resection at 12 months of age. The second child developed epilepsy at 3 years 3 months, and between 5 years 9 months and 6 years 1 month he became aphasic (Landau-Kleffner syndrome) and lost social functioning, manifesting a very severe behavior disorder. He exhibited a significant improvement in communication, social functioning, and behavior after left multiple subpial transections. Both children manifested evidence of subclinical seizure activity in both temporal lobes. Their clinical picture was one of combined language and autistic regression, and the autistic features demonstrated a clear response to surgical treatment. We suggest that in pediatric epilepsy surgical programs, autistic regression should prompt urgent investigation if drug treatment is not effective. (C) 1997 by Elsevier Science Inc.
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页码:137 / 140
页数:4
相关论文
共 8 条
[1]  
Beaumanoir Anne, 1992, P231
[2]  
GILLBERG C, 1992, DIS NERVOUS SYSTEM C, P1295
[3]  
GILLBERG G, 1992, CLIN DEV MED, P74
[4]   SYNDROME OF ACQUIRED APHASIA WITH CONVULSIVE DISORDER IN CHILDREN [J].
LANDAU, WM ;
KLEFFNER, FR .
NEUROLOGY, 1957, 7 (08) :523-530
[5]  
LORD C, 1994, CHILD ADOLESCENT PSY, P569
[6]   Landau-Kleffner syndrome - Treatment with subpial intracortical transection [J].
Morrell, F ;
Whisler, WW ;
Smith, MC ;
Hoeppner, TJ ;
deToledoMorrell, L ;
PierreLouis, SJC ;
Kanner, AM ;
Buelow, JM ;
Ristanovic, R ;
Bergen, D ;
Chez, M ;
Hasegawa, H .
BRAIN, 1995, 118 :1529-1546
[7]   DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMOR - FEATURES IN 16 PATIENTS [J].
RAYMOND, AA ;
HALPIN, SFS ;
ALSANJARI, N ;
COOK, MJ ;
KITCHEN, ND ;
FISH, DR ;
STEVENS, JM ;
HARDING, BN ;
SCARAVILLI, F ;
KENDALL, B ;
SHORVON, SD ;
NEVILLE, BGR .
BRAIN, 1994, 117 :461-475
[8]   OUTCOMES IN 248 PATIENTS WHO HAD DIAGNOSTIC EVALUATIONS FOR EPILEPSY SURGERY [J].
VICKREY, BG ;
HAYS, RD ;
RAUSCH, R ;
ENGEL, J ;
VISSCHER, BR ;
ARY, CM ;
ROGERS, WH ;
BROOK, RH .
LANCET, 1995, 346 (8988) :1445-1449