Cancer Pharmacogenomics: Early Promise, But Concerted Effort Needed

被引：107

作者：

McLeod, Howard L. ^{[1
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机构：

[1] Univ N Carolina, Inst Pharmacogen & Individualized Therapy, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA

来源：

SCIENCE | 2013年 / 339卷 / 6127期

关键词：

GENOME-WIDE ASSOCIATION; PLASMA-CONCENTRATIONS; LUNG-CANCER; TAMOXIFEN; CYP2D6; CHEMOTHERAPY; WOMEN;

D O I：

10.1126/science.1234139

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The past decade has brought together substantial advances in human genome analysis and a maturation of understanding of tumor biology. Although there is much progress still to be made, there are now several prominent examples in which tumor-associated somatic mutations have been used to identify cellular signaling pathways in tumors. This in turn has led to the development of targeted therapies, with somatic mutations serving as genomic predictors of tumor response and providing new leads for drug development. There is also a realization that germline DNA variants can help optimize cancer drug dosing and predict the susceptibility of patients to the adverse side effects of these drugs-knowledge that ultimately can be used to improve the benefit: risk ratio of cancer treatment for individual patients.

引用

页码：1563 / 1566

页数：4

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