A nucleotide deletion in exon 4 is responsible for an HLA-A null allele (A*0105N)

被引：11

作者：

Poli, F

Bianchi, P

Scalamogna, M

Crespiatico, L

Ghidoli, N

Puglisi, G

Sirchia, G

机构：

[1] Osped Maggiore, Policlin IRCCS, Ctr Trasfusionale & Immunol Trapianti, I-20122 Milan, Italy

[2] Osped Maggiore, Policlin IRCCS, Div Ematol, I-20122 Milan, Italy

来源：

TISSUE ANTIGENS | 1999年 / 54卷 / 03期

关键词：

HLA-A null allele; MHC;

D O I：

10.1034/j.1399-0039.1999.540315.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We report herein the identification of a new HLA A null allele. This allele, A*0105N, was detected during histocompatibility testing of a cord blood donor and the respective mother, Serologic typing results contrasted those obtained with DNA typing that alone showed the presence of HLA-A*01. This A*0105N was due to a nucleotide deletion in exon 4 that altered the reading frame, causing a premature termination.

引用

页码：300 / 302

页数：3

共 10 条

[1] CHARACTERIZATION OF DONOR-DIRECTED ANTIBODY CLASS IN THE POSTTRANSPLANT PERIOD USING FLOW-CYTOMETRY IN RENAL-TRANSPLANTATION [J].

ALHUSSEIN, KA ;

SHENTON, BK ;

BELL, A ;

TALBOT, D ;

CLARK, KR ;

RIGG, KM ;

FORSYTHE, JLR ;

PROUD, G ;

TAYLOR, RMR .

TRANSPLANT INTERNATIONAL, 1994, 7 (03) :182-189

[2] Nomenclature for factors of the HLA system, 1996 [J].

Bodmer, JG ;

Marsh, SGE ;

Albert, ED ;

Bodmer, WF ;

Bontrop, RE ;

Charron, D ;

Dupont, B ;

Erlich, HA ;

Fauchet, R ;

Mach, B ;

Mayr, WR ;

Parham, P ;

Sasazuki, T ;

Schreuder, GMT ;

Strominger, JL ;

Svejgaard, A ;

Terasaki, PI .

TISSUE ANTIGENS, 1997, 49 (03) :297-321

[3]

JOHNSTONDOW L, 1997, GENETIC DIVERSITY HL, P250

[4] A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA-A*01 allele [J].

Laforet, M ;

Froelich, N ;

Parissiadis, A ;

Pfeiffer, B ;

Schell, A ;

Faller, B ;

WoehlJaegle, ML ;

Cazenave, JP ;

Tongio, MM .

TISSUE ANTIGENS, 1997, 50 (04) :347-350

[5]

LARDY NM, 1992, J IMMUNOL, V148, P2572

[6]

Lazzari L, 1996, J Hematother, V5, P117, DOI 10.1089/scd.1.1996.5.117

[7] A SIMPLE SALTING OUT PROCEDURE FOR EXTRACTING DNA FROM HUMAN NUCLEATED CELLS [J].

MILLER, SA ;

DYKES, DD ;

POLESKY, HF .

NUCLEIC ACIDS RESEARCH, 1988, 16 (03) :1215-1215

[8] HLA-DR TYPING BY PCR AMPLIFICATION WITH SEQUENCE-SPECIFIC PRIMERS (PCR-SSP) IN 2 HOURS - AN ALTERNATIVE TO SEROLOGICAL DR TYPING IN CLINICAL-PRACTICE INCLUDING DONOR-RECIPIENT MATCHING IN CADAVERIC TRANSPLANTATION [J].

OLERUP, O ;

ZETTERQUIST, H .

TISSUE ANTIGENS, 1992, 39 (05) :225-235

[9] HLA-A typing: comparison between serology, the amplification refractory mutation system with polymerase chain reaction and sequencing [J].

Pera, C ;

Delfino, L ;

Morabito, A ;

Longo, A ;

JohnstonDow, L ;

White, CB ;

Colonna, M ;

Ferrara, GB .

TISSUE ANTIGENS, 1997, 50 (04) :372-379

[10]

VARTDAL F, 1986, TISSUE ANTIGENS, V28, P301

← 1 →