Rapid Diagnosis of CNS Tuberculosis by a T-Cell Interferon-γ Release Assay on Cerebrospinal Fluid Mononuclear Cells

被引：37

作者：

Koesters, K. ^{[2
]}

Nau, R. ^{[3
]}

Bossink, A. ^{[4
]}

Greiffendorf, I. ^{[2
]}

Jentsch, M. ^{[2
]}

Ernst, M. ^{[5
]}

Thijsen, S. ^{[4
]}

Hinks, T. ^{[6
]}

Lalvani, A. ^{[6
]}

Lange, C. ^{[1
,5
]}

机构：

[1] Res Ctr Borstel, Med Clin, Div Clin Infect Dis, D-23845 Borstel, Germany

[2] Klinikum Krefeld, Krefeld, Germany

[3] Univ Hosp Gottingen, Gottingen, Germany

[4] Diakonessenhuis Utrecht, Utrecht, Netherlands

[5] Res Ctr Borstel, Borstel, Germany

[6] Univ London Imperial Coll Sci Technol & Med, London, England

来源：

INFECTION | 2008年 / 36卷 / 06期

关键词：

D O I：

10.1007/s15010-007-7316-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Central nervous system tuberculosis remains a clinical diagnostic challenge. The ex vivo Mycobacterium tuberculosis-specific enzyme-linked immunospot assay (ELISPOT) is a novel assay for the rapid detection of M. tuberculosis-specific T-lymphocytes in the peripheral blood. However, when performed on peripheral blood, this assay cannot distinguish between active tuberculosis or latent tuberculosis infection. On the assumption that M. tuberculosis-specific T-lymphocytes migrate to sites of infection, we were able to demonstrate high levels of M. tuberculosis-specific cells by ELISPOT in the cerebrospinal fluid of a patient with tuberculous meningitis and intracerebral tuberculoma four weeks before cerebrospinal fluid culture became positive for M. tuberculosis by culture.

引用

页码：597 / 600

页数：4

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