The expanding genetic overlap between multiple sclerosis and type I diabetes

被引：127

作者：

Booth, David R. ^{[2
]}

Heard, Robert N. ^{[2
]}

Stewart, Graeme J. ^{[2
]}

Goris, An ^{[3
]}

Dobosi, Rita ^{[3
]}

Dubois, Benedicte ^{[3
]}

Lorentzen, Aslaug R. ^{[4
,5
]}

Celius, Elisabeth G. ^{[6
]}

Harbo, Hanne F. ^{[6
]}

Spurkland, Anne ^{[7
]}

Olsson, Tomas ^{[8
]}

Kockum, Ingrid ^{[8
]}

Link, Jenny ^{[8
]}

Hillert, Jan ^{[8
]}

Ban, Maria ^{[1
]}

Baker, Amie

Sawcer, Stephen

Compston, Alastair

Mihalova, Tania ^{[9
]}

Strange, Richard ^{[9
]}

Hawkins, Clive ^{[9
]}

Ingram, Gillian ^{[10
]}

Robertson, Neil P. ^{[10
]}

De Jager, Philip L. ^{[11
,12
]}

Hafler, David A. ^{[11
,12
]}

Barcellos, Lisa F. ^{[13
]}

Ivinson, Adrian J. ^{[14
]}

Pericak-Vance, Margaret ^{[16
]}

Oksenberg, Jorge R. ^{[15
]}

Hauser, Stephen L. ^{[15
]}

McCauley, Jacob L. ^{[17
]}

Sexton, David ^{[17
]}

Haines, Jonathan ^{[17
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Dept Clin Neurosci, Cambridge CB2 2QQ, England

[2] Univ Sydney, Westmead Hosp, Inst Immunol & Allergy Res, Westmead Millennium Inst, Westmead, NSW 2145, Australia

[3] Katholieke Univ Leuven, Sect Expt Neurol, B-3000 Louvain, Belgium

[4] Univ Oslo, Fac Div Ulleval, Dept Neurol, Univ Hosp, Oslo, Norway

[5] Univ Hosp, Rikshosp, Inst Immunol, N-0027 Oslo, Norway

[6] Ullevaal Univ Hosp, Dept Neurol, N-0407 Oslo, Norway

[7] Univ Oslo, Inst Basal Med Sci, N-0317 Oslo, Norway

[8] Karolinska Hosp, Dept Clin Neurosci, Ctr Mol Med CMM, S-17176 Stockholm, Sweden

[9] Keele Univ, Sch Med, Dept Neurol & Human Genom, Stoke On Trent ST4 7LN, Staffs, England

[10] Univ Wales Hosp, Dept Neurol, Cardiff CF14 4XW, S Glam, Wales

[11] Brigham & Womens Hosp, Ctr Neurol Dis, Div Mol Immunol, Boston, MA 02115 USA

[12] Harvard Univ, Sch Med, Partners Healthcare Ctr Genet & Genom, Boston, MA USA

[13] Univ Calif Berkeley, Berkeley, CA 94720 USA

[14] Harvard Univ, Sch Med, Harvard NeuroDiscovery Ctr, Boston, MA USA

[15] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[16] Univ Miami, Sch Med, Miami, FL USA

[17] Vanderbilt Univ, Med Ctr, Ctr Human Genet Res, Nashville, TN USA

来源：

GENES AND IMMUNITY | 2009年 / 10卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

INTERLEUKIN-7; RECEPTOR; AUTOIMMUNE-DISEASES; DIAGNOSTIC-CRITERIA; RISK; ASSOCIATION; POLYMORPHISMS; MHC2TA; SUSCEPTIBILITY; EXPANSION; ARTHRITIS;

D O I：

10.1038/gene.2008.83

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Familial clustering of autoimmune disease is well recognized and raises the possibility that some susceptibility genes may predispose to autoimmunity in general. In light of this observation, it might be expected that some of the variants of established relevance in one autoimmune disease may also be relevant in other related conditions. On the basis of this hypothesis, we tested seven single nucleotide polymorphisms (SNPs) that are known to be associated with type I diabetes in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10 296 unrelated controls. Two of these seven SNPs showed evidence of association with multiple sclerosis; that is rs12708716 from the CLEC16A gene (P=1.6 x 10(-16)) and rs763361 from the CD226 gene (P = 5.4 x 10(-8)). These findings thereby identify two additional multiple sclerosis susceptibility genes and lend support to the notion of autoimmune susceptibility genes.

引用

页码：11 / 14

页数：4

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