Anti-GD1a antibodies from an acute motor axonal neuropathy patient selectively bind to motor nerve fiber nodes of Ranvier

被引：21

作者：

De Angelis, MV ^{[1
]}

Di Muzio, A ^{[1
]}

Lupo, S ^{[1
]}

Gambi, D ^{[1
]}

Uncini, A ^{[1
]}

Lugaresi, A ^{[1
]}

机构：

[1] Univ Gabriele Annunzio, Ctr Neuromuscular Dis, I-66013 Chieti, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 121卷 / 1-2期

关键词：

acute motor axonal neuropathy; GD1a ganglioside; Guillain-Barre syndrome; immuno-histochemistry; node of Ranvier; botulinum toxin;

D O I：

10.1016/S0165-5728(01)00434-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute motor axonal neuropathy (AMAN) is associated with high titer anti-GDla antibodies. We have found that very high titer IgG anti-GDla antibodies (Ab) from one AMAN patient selectively bind to motor, but not sensory, nerve nodes of Ranvier. Binding is abolished by preadsorption with GDla. Sera negative for Ab do not immunostain motor and sensory nerve roots. We have also found that botulinum toxin A (BTA), which binds to GDla, stains both motor and sensory nerve nodes of Ranvier. Our results strongly support the pathogenetic role of anti-GDla antibodies in AMAN. Why BTA also binds to sensory fibers still remains to be elucidated, although the different size of BTA and its specificity to other gangliosides present in sensory axons might represent important factors. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：79 / 82

页数：4

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