Early management of severe traumatic brain injury

被引：453

作者：

Rosenfeld, Jeffrey V. ^{[1
,2
]}

Maas, Andrew I. ^{[3
,4
]}

Bragge, Peter ^{[2
]}

Morganti-Kossmann, M. Cristina ^{[2
]}

Manley, Geoffrey T. ^{[5
,6
]}

Gruen, Russell L. ^{[2
]}

机构：

[1] Monash Univ, Alfred Hosp, Dept Neurosurg, Melbourne, Vic 3181, Australia

[2] Monash Univ, Alfred Hosp, Natl Trauma Res Inst, Melbourne, Vic 3181, Australia

[3] Univ Antwerp Hosp, Dept Neurosurg, Edegem, Belgium

[4] Univ Antwerp, Edegem, Belgium

[5] San Francisco Gen Hosp, San Francisco, CA 94110 USA

[6] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

LANCET | 2012年 / 380卷 / 9847期

基金：

英国医学研究理事会;

关键词：

EARLY DECOMPRESSIVE CRANIECTOMY; HEAD-INJURY; PROGNOSTIC MODELS; CYCLOSPORINE-A; OXYGEN; HYPOTHERMIA; ERYTHROPOIETIN; MULTICENTER; MORTALITY; OUTCOMES;

D O I：

10.1016/S0140-6736(12)60864-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe traumatic brain injury remains a major health-care problem worldwide. Although major progress has been made in understanding of the pathophysiology of this injury, this has not yet led to substantial improvements in outcome. In this report, we address present knowledge and its limitations, research innovations, and clinical implications. Improved outcomes for patients with severe traumatic brain injury could result from progress in pharmacological and other treatments, neural repair and regeneration, optimisation of surgical indications and techniques, and combination and individually targeted treatments. Expanded classification of traumatic brain injury and innovations in research design will underpin these advances. We are optimistic that further gains in outcome for patients with severe traumatic brain injury will be achieved in the next decade.

引用

页码：1088 / 1098

页数：11

共 112 条

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