The cancer paradigm of severe pulmonary arterial hypertension

被引：209

作者：

Rai, Pradeep R. ^{[2
,3
]}

Cool, Carlyne D. ^{[2
,3
]}

King, Judy A. C. ^{[4
]}

Stevens, Troy ^{[4
]}

Burns, Nana ^{[3
]}

Winn, Robert A. ^{[3
]}

Kasper, Michael ^{[5
]}

Voelkel, Norbert F. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Div Pulm & Crit Care Med, Richmond, VA 23298 USA

[2] Univ Colorado, Dept Pathol, Denver, CO 80202 USA

[3] Hlth Sci Ctr, Denver, CO 80202 USA

[4] Univ S Alabama, Ctr Lung Biol, Mobile, AL 36688 USA

[5] Gustav Carus Univ, TH, Dresden, Germany

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2008年 / 178卷 / 06期

关键词：

pulmonary arterial hypertension; plexiform lesions; angiogenesis; cancer;

D O I：

10.1164/rccm.200709-1369PP

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The plexiform lesions of severe pulmonary arterial hypertension (PAH) are similar in histologic appearance, whether the disease is idiopathic or secondary. Both forms of the disease show actively proliferating endothelial cells without evidence of apoptosis. Here, we discuss the pathobiology of the atypical, angioproliferative endothelial cells in severe PAH. The concept of the endothelial cell as a "quasi-malignant" cell provides a new framework for antiproliferative, antiangiogenic therapy in severe PAH.

引用

页码：558 / 564

页数：7

共 77 条

[1] Loss of caveolin and heme oxygenase expression in severe pulmonary hypertension [J].

Achcar, ROD ;

Demura, Y ;

Rai, PR ;

Taraseviciene-Stewart, L ;

Kasper, M ;

Voelkel, NF ;

Cool, CD .

CHEST, 2006, 129 (03) :696-705

[2] BMPR2 Gene Rearrangements Account for a Significant Proportion of Mutations in Familial and Idiopathic Pulmonary Arterial Hypertension [J].

Aldred, Micheala A. ;

Vijayakrishnan, Jairam ;

James, Victoria ;

Soubrier, Florent ;

Gomez-Sanchez, Miguel A. ;

Martensson, Gunnar ;

Galie, Nazzareno ;

Manes, Alessandra ;

Corris, Paul ;

Simonneau, Gerald ;

Humbert, Marc ;

Morrell, Nicholas W. ;

Trembath, Richard C. .

HUMAN MUTATION, 2006, 27 (02) :212-213

[3] Peroxisome proliferator-activated receptor gamma (PPARγ) expression is decreased in pulmonary hypertension and affects endothelial cell growth [J].

Ameshima, S ;

Golpon, H ;

Cool, CD ;

Chan, D ;

Vandivier, RW ;

Gardai, SJ ;

Wick, M ;

Nemenoff, RA ;

Geraci, MW ;

Voelkel, NF .

CIRCULATION RESEARCH, 2003, 92 (10) :1162-1169

[4] NITRIC-OXIDE AND CGMP CAUSE VASORELAXATION BY ACTIVATION OF A CHARYBDOTOXIN-SENSITIVE K-CHANNEL BY CGMP-DEPENDENT PROTEIN-KINASE [J].

ARCHER, SL ;

HUANG, JMC ;

HAMPL, V ;

NELSON, DP ;

SHULTZ, PJ ;

WEIR, EK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7583-7587

[5] BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK [J].

Beck, Stayce E. ;

Jung, Barbara H. ;

Del Rosario, Eunice ;

Gomez, Jessica ;

Carethers, John M. .

CELLULAR SIGNALLING, 2007, 19 (07) :1465-1472

[6] Signal transducer and activator of transcription proteins in leukemias [J].

Benekli, M ;

Baer, MR ;

Baumann, H ;

Wetzler, M .

BLOOD, 2003, 101 (08) :2940-2954

[7] The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted [J].

Bonnet, Sebastien ;

Rochefort, Gael ;

Sutendra, Gopinath ;

Archer, Stephen L. ;

Haromy, Alois ;

Webster, Linda ;

Hashimoto, Kyoko ;

Bonnet, Sandra N. ;

Michelakis, Evangelos D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (27) :11418-11423

[8] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth [J].

Bonnet, Sebastien ;

Archer, Stephen L. ;

Allalunis-Turner, Joan ;

Haromy, Alois ;

Beaulieu, Christian ;

Thompson, Richard ;

Lee, Christopher T. ;

Lopaschuk, Gary D. ;

Puttagunta, Lakshmi ;

Bonnet, Sandra ;

Harry, Gwyneth ;

Hashimoto, Kyoko ;

Porter, Christopher J. ;

Andrade, Miguel A. ;

Thebaud, Bernard ;

Michelakis, Evangelos D. .

CANCER CELL, 2007, 11 (01) :37-51

[9] Overexpression of human KCNA5 increases IK(V) and enhances apoptosis [J].

Brevnova, EE ;

Platoshyn, O ;

Zhang, S ;

Yuan, JXJ .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2004, 287 (03) :C715-C722

[10]

Buchynska L. G., 2006, Experimental Oncology, V28, P152

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