Cloning of a putative ligand for the T1/ST2 receptor

被引：62

作者：

Gayle, MA

Slack, JL

Bonnert, TP

Renshaw, BR

Sonoda, G

Taguchi, T

Testa, JR

Dower, SK

Sims, JE

机构：

[1] IMMUNEX CORP,SEATTLE,WA 98101

[2] FOX CHASE CANC CTR,PHILADELPHIA,PA 19111

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1996年 / 271卷 / 10期

关键词：

D O I：

10.1074/jbc.271.10.5784

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite this sequence similarity, me have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell surface protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays.

引用

收藏

页码：5784 / 5789

页数：6

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