Increased EEG gamma band activity in Alzheimer's disease and mild cognitive impairment

被引：128

作者：

van Deursen, J. A. ^{[1
,2
]}

Vuurman, E. F. P. M. ^{[1
,2
]}

Verhey, F. R. J. ^{[1
]}

van Kranen-Mastenbroek, V. H. J. M. ^{[3
]}

Riedel, W. J. ^{[2
]}

机构：

[1] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Psychiat & Neuropsychol, NL-6200 Maastricht, Netherlands

[2] Maastricht Univ, Fac Psychol, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands

[3] Maastricht Univ Hosp, Dept Clin Neurophysiol, Maastricht, Netherlands

来源：

JOURNAL OF NEURAL TRANSMISSION | 2008年 / 115卷 / 09期

关键词：

EEG; induced gamma band; Alzheimer's disease; mild cognitive impairment; sensitivity; reliability;

D O I：

10.1007/s00702-008-0083-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

High frequency (30-70 Hz) gamma band oscillations in the human electro-encephalogram (EEG) are thought to reflect perceptual and cognitive processes. It is therefore interesting to study these measures in cognitive impairment and dementia. To evaluate gamma band oscillations as a diagnostic biomarker in Alzheimer's disease (AD) and mild cognitive impairment (MCI), 15 psychoactive drug naive AD patients, 20 MCI patients and 20 healthy controls participated in this study. Gamma band power (GBP) was measured in four conditions viz. resting state, music listening, story listening and visual stimulation. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment one week after the first. The overall TRR was high. Elevated GBP was observed in AD when compared to MCI and control subjects in all conditions. The results suggest that elevated GBP is a reproducible and sensitive measure for cognitive dysfunction in AD in comparison with MCI and controls.

引用

页码：1301 / 1311

页数：11

共 42 条

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