Systemic Lupus Erythematosus: An Overview

被引：48

作者：

Askanase, Anca ^{[1
]}

Shum, Katrina ^{[1
]}

Mitnick, Hal ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Rheumatol, New York, NY 10016 USA

来源：

SOCIAL WORK IN HEALTH CARE | 2012年 / 51卷 / 07期

关键词：

lupus; medical; diagnosis; treatment; MYCOPHENOLATE-MOFETIL; REVISED CRITERIA; SERUM FACTOR; CLASSIFICATION; PREVALENCE; NEPHRITIS; RITUXIMAB; ANTIBODY; HISTORY; COHORT;

D O I：

10.1080/00981389.2012.683369

中图分类号：

C916 [社会工作、社会管理、社会规划];

学科分类号：

030309 [社会工作];

摘要：

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology in which the normal immune responses are directed against healthy organs and tissues. The dis-regulated immune system produces antibodies that attack the skin, joints, kidneys, heart, and brain. Some people experience mild rashes and arthritis, others suffer debilitating fever, fatigue, joint pain, and severe organ and/or life-threatening disease. This article provides a medical overview of the epidemiology of SLE, the challenges of diagnosing SLE, the complexity of the clinical manifestations and treatment issues, and the impact of SLE on patients' lives. We also discuss the progress in understanding the disease and its therapy over the last century.

引用

页码：576 / 586

页数：11

共 37 条

[1]

Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort [J].

Alarcon-Segovia, D ;

Alarcón-Riquelme, ME ;

Cardiel, MH ;

Caeiro, F ;

Massardo, L ;

Villa, AR ;

Pons-Estel, BA .

ARTHRITIS AND RHEUMATISM, 2005, 52 (04) :1138-1147

[2]

Mycophenolate mofetil and its mechanisms of action [J].

Allison, AC ;

Eugui, EM .

IMMUNOPHARMACOLOGY, 2000, 47 (2-3) :85-118

[3]

STUDIES IN FAMILIAL SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

ARNETT, FC ;

SHULMAN, LE .

MEDICINE, 1976, 55 (04) :313-322

[4]

THERAPY OF LUPUS NEPHRITIS - CONTROLLED TRIAL OF PREDNISONE AND CYTOTOXIC DRUGS [J].

AUSTIN, HA ;

KLIPPEL, JH ;

BALOW, JE ;

LERICHE, NGH ;

STEINBERG, AD ;

PLOTZ, PH ;

DECKER, JL .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (10) :614-619

[5]

Mortality in systemic lupus erythematosus [J].

Bernatsky, S. ;

Boivin, J. -F. ;

Joseph, L. ;

Manzi, S. ;

Ginzler, E. ;

Gladman, D. D. ;

Urowitz, M. ;

Fortin, P. R. ;

Petri, M. ;

Barr, S. ;

Gordon, C. ;

Bae, S. -C. ;

Isenberg, D. ;

Zoma, A. ;

Aranow, C. ;

Dooley, M. -A. ;

Nived, O. ;

Sturfelt, G. ;

Steinsson, K. ;

Alarcon, G. ;

Senecal, J. -L. ;

Zummer, M. ;

Hanly, J. ;

Ensworth, S. ;

Pope, J. ;

Edworthy, S. ;

Rahman, A. ;

Sibley, J. ;

El-Gabalawy, H. ;

McCarthy, T. ;

Pierre, Y. St. ;

Clarke, A. ;

Ramsey-Goldman, R. .

ARTHRITIS AND RHEUMATISM, 2006, 54 (08) :2550-2557

[6]

BIELSCHOWSKY M, 1959, P U OTAGO MED SCH, V37

[7]

Blotzer J W, 1983, Md State Med J, V32, P439

[8]

Prevalence of adult systemic lupus erythematosus in California and Pennsylvania in 2000: estimates obtained using hospitalization data [J].

Chakravarty, Eliza F. ;

Bush, Thomas M. ;

Manzi, Susan ;

Clarke, Ann E. ;

Ward, Michael M. .

ARTHRITIS AND RHEUMATISM, 2007, 56 (06) :2092-2094

[9]

THE PRECIPITIN REACTION BETWEEN DNA AND A SERUM FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUS [J].

DEICHER, HRG ;

HOLMAN, HR ;

KUNKEL, HG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1959, 109 (01) :97-114

[10]

FRIOU GJ, 1957, J CLIN INVEST, V36, P890

← 1 2 3 4 →