Stereoselective synthesis of 7α- and 7β-aminocholestanol as potent fungicidal drugs

被引：13

作者：

Fouace, S ^{[1
]}

El kihel, L ^{[1
]}

Dherbomez, M ^{[1
]}

Letourneux, Y ^{[1
]}

机构：

[1] Univ La Rochelle, Lab Synthese & Etude Subst Nat Activ Biol, F-17042 La Rochelle, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(01)00609-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potentially lymphotropic 7 alpha- and 7 beta -aminocholestanol were stereo selectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3011 / 3014

页数：4

共 18 条

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