Lipid signaling in CD95-mediated apoptosis

被引：27

作者：

Malisan, F ^{[1
]}

Testi, R ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy

来源：

FEBS LETTERS | 1999年 / 452卷 / 1-2期

关键词：

apoptosis; CD95; sphingomyelinase; ceramide; disialoganglioside GD3; mitochondrion;

D O I：

10.1016/S0014-5793(99)00543-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors including CD95. Ceramide generation also regulates glycosphingolipid and ganglioside metabolism. In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells. (C) 1999 Federation of European Biochemical Societies.

引用

页码：100 / 103

页数：4

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