A mimicry of primary amines by bis-secondary diamines as components in the Ugi four-component reaction

被引：79

作者：

Giovenzana, GB

Tron, GC

Di Paola, S

Menegotto, IG

Pirali, T

机构：

[1] Univ Piemonte Orientale, DiSCAFF, I-28100 Novara, Italy

[2] Univ Piemonte Orientale, Drug & Food Biotechnol Ctr, I-28100 Novara, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 07期

关键词：

amines; isocyanides; molecular diversity; multicomponent reactions;

D O I：

10.1002/anie.200503095

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Splitting the amine! The Ugi four-component reaction (Ugi 4CR) relies on the presence of a component with a primary amino group. This protocol has been modified by splitting" the primary amine into two secondary amines. The resulting variant of the Ugi 4CR proceeds with good to excellent yield and widens the versatility of the original multicomponent reaction by enabling variation of the molecular backbone. (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA."

引用

页码：1099 / 1102

页数：4

共 27 条

[1] Unification of reaction metrics for green chemistry II: Evaluation of named organic reactions and application to reaction discovery [J].