Genomic-scale prioritization of drug targets: the TDR Targets database

被引：221

作者：

Agueero, Fernan ^{[1
]}

Al-Lazikani, Bissan ^{[2
]}

Aslett, Martin ^{[3
]}

Berriman, Matthew ^{[3
]}

Buckner, Frederick S. ^{[4
]}

Campbell, Robert K. ^{[5
,9
]}

Carmona, Santiago ^{[1
]}

Carruthers, Ian M. ^{[2
]}

Chan, A. W. Edith ^{[2
]}

Chen, Feng ^{[6
,7
]}

Crowther, Gregory J. ^{[4
]}

Doyle, Maria A. ^{[8
]}

Hertz-Fowler, Christiane ^{[3
]}

Hopkins, Andrew L. ^{[9
]}

McAllister, Gregg ^{[10
]}

Nwaka, Solomon ^{[11
]}

Overington, John P. ^{[2
]}

Pain, Arnab ^{[3
]}

Paolini, Gala V. ^{[9
]}

Pieper, Ursula ^{[12
]}

Ralph, Stuart A. ^{[8
]}

Riechers, Aaron ^{[4
]}

Roos, David S. ^{[6
,7
]}

Sali, Andrej ^{[12
]}

Shanmugam, Dhanasekaran ^{[6
,7
]}

Suzuki, Takashi ^{[3
]}

Van Voorhis, Wesley C. ^{[4
]}

Verlinde, Christophe L. M. J. ^{[13
]}

机构：

[1] Univ Nacl Gen San Martin, Inst Invest Biotecnol, RA-1650 Buenos Aires, DF, Argentina

[2] BioFocus DPI, London WC1A 1NU, England

[3] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

[4] Univ Washington, Div Allergy & Infect Dis, Dept Med, Seattle, WA 98195 USA

[5] Marine Biol Lab, Woods Hole, MA 02543 USA

[6] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[7] Univ Penn, Penn Genom Inst, Philadelphia, PA 19104 USA

[8] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia

[9] Pfizer Global Res & Dev, Sandwich CT13 9NJ, Kent, England

[10] Brandeis Univ, Waltham, MA 02453 USA

[11] WHO, Special Programme Res & Training Trop Dis, CH-1211 Geneva 27, Switzerland

[12] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

[13] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 11期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrd2684

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.

引用

页码：900 / 907

页数：8

共 27 条

[1]

ALLAZIKANI B, 2007, BIOINFORMATICS GENOM, V3, P1315

[2] Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii [J].

Chaudhary, K ;

Darling, JA ;

Fohl, LM ;

Sullivan, WJ ;

Donald, RGK ;

Pfefferkorn, ER ;

Ullman, B ;

Roos, DS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (30) :31221-31227

[3] Assessing Performance of Orthology Detection Strategies Applied to Eukaryotic Genomes [J].

Chen, Feng ;

Mackey, Aaron J. ;

Vermunt, Jeroen K. ;

Roos, David S. .

PLOS ONE, 2007, 2 (04)

[4] OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups [J].

Chen, Feng ;

Mackey, Aaron J. ;

Stoeckert, Christian J., Jr. ;

Roos, David S. .

NUCLEIC ACIDS RESEARCH, 2006, 34 :D363-D368

[5] Experimental determination and system level analysis of essential genes in Escherichia coli MG1655 [J].

Gerdes, SY ;

Scholle, MD ;

Campbell, JW ;

Balázsi, G ;

Ravasz, E ;

Daugherty, MD ;

Somera, AL ;

Kyrpides, NC ;

Anderson, I ;

Gelfand, MS ;

Bhattacharya, A ;

Kapatral, V ;

D'Souza, M ;

Baev, MV ;

Grechkin, Y ;

Mseeh, F ;

Fonstein, MY ;

Overbeek, R ;

Barabási, AL ;

Oltvai, ZN ;

Osterman, AL .

JOURNAL OF BACTERIOLOGY, 2003, 185 (19) :5673-5684

[6]

Ghedin E, 2007, SCIENCE, V317, P1756, DOI 10.1126/science.1145406

[7] Prioritizing genomic drug targets in pathogens:: Application to Mycobacterium tuberculosis [J].

Hasan, Samiul ;

Daugelat, Sabine ;

Rao, P. S. Srinivasa ;

Schreiber, Mark .

PLOS COMPUTATIONAL BIOLOGY, 2006, 2 (06) :539-550

[8] Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis [J].

Heby, O. ;

Persson, L. ;

Rentala, M. .

AMINO ACIDS, 2007, 33 (02) :359-366

[9] The druggable genome [J].

Hopkins, AL ;

Groom, CR .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (09) :727-730

[10] Mission possible [J].

Hopkins, Andrew L. ;

Witty, Michael J. ;

Nwaka, Solomon .

NATURE, 2007, 449 (7159) :166-169

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