Bone marrow uptake of fluorine-18-fluorodeoxyglucose following treatment with hematopoietic growth factors: Initial evaluation

被引:36
作者
Knopp, MV [1 ]
Bischoff, H [1 ]
Rimac, A [1 ]
Oberdorfer, F [1 ]
vanKaick, G [1 ]
机构
[1] CHEST HOSP HEIDELBERG ROHRBACH,HEIDELBERG,GERMANY
来源
NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 06期
关键词
fluorine-18-fluorodeoxyglucose; positron emission tomography; bone marrow; hematopoietic growth factors;
D O I
10.1016/0969-8051(96)00085-6
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Hematopoietic growth factors (HGF) such as G-CSF and GM-CSF stimulate cell growth of the bone marrow and thereby mitigate the myelotoxic effect of chemotherapy. Using F-18-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) for therapy response monitoring of patients with small-cell lung cancer, both an extension and an intensification of thoracic bone marrow uptake were noted in patients treated with HGF (n = 5) compared to those patients without HGF supplementation (n = 11). FDG uptake was a very sensitive marker of stimulated hematopoiesis, and both the extension and the intensification of uptake have to be noted during HGF therapy.
引用
收藏
页码:845 / 849
页数:5
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