Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques

被引：39

作者：

Barcia, Carlos ^{[1
]}

Maria Ros, Carmen ^{[1
]}

Ros-Bernal, Francisco ^{[1
]}

Gomez, Aurora ^{[1
]}

Annese, Valentina ^{[1
]}

Angeles Carrillo-de Sauvage, Maria ^{[1
]}

Enrique Yuste, Jose ^{[1
]}

Maria Campuzano, Carmen

de Pablos, Vicente ^{[1
]}

Fernandez-Villalba, Emiliano ^{[1
]}

Trinidad Herrero, Maria ^{[1
]}

机构：

[1] Univ Murcia, Sch Med, Ctr Invest Biomed Red Enfermedades Neurodegenerat, E-30071 Murcia, Spain

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 261卷 / 1-2期

关键词：

Parkinson's disease; MPTP; Dopaminergic degeneration; Cell polarity; Inflammation; Microglial motility; REACTIVE MICROGLIA; IN-VIVO; DISEASE; NEURONS; MONKEYS; MPTP; ACTIVATION; BRAIN; EXPOSURE; CELLS;

D O I：

10.1016/j.jneuroim.2013.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In this study, we report the microanatomical details of microglia and the relationship between microglia and neurons in the substantia nigra pars compacta of Parkinsonian monkeys years after insult with MPTP. We observed that microglial cells appear polarized toward dopaminergic neurons in MPTP-treated macaques compared to untreated animals and present clear phagocytic characteristics, such as engulfing gliaptic contacts, an increase in Golgi apparatus protein machinery and ball-and-chain phagocytic buds. These results demonstrate that activated microglia maintain phagocytic characteristics years after neurotoxin insult, and phagocytosis may be a key contributor to the neurodegenerative process. (C) 2013 Elsevier B.V. All rights reserved.

引用

收藏

页码：60 / 66

页数：7

相关论文

共 21 条

[1]

Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure [J].

Barcia, C ;

Bahillo, AS ;

Fernández-Villalba, E ;

Bautista, V ;

Poza, MPY ;

Fernández-Barreiro, A ;

Hirsch, EC ;

Herrero, MT .

GLIA, 2004, 46 (04) :402-409

[2]

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease [J].

Barcia, C. ;

Ros, C. M. ;

Annese, V. ;

Gomez, A. ;

Ros-Bernal, F. ;

Aguado-Yera, D. ;

Martinez-Pagan, M. E. ;

de Pablos, V. ;

Fernandez-Villalba, E. ;

Herrero, M. T. .

CELL DEATH & DISEASE, 2011, 2 :e142-e142

[3]

Circadian determinations of cortisol, prolactin and melatonin in chronic methyl-phenyl-tetrahydropyridine-treated monkeys [J].

Barcia, C ;

Bautista, V ;

Sánchez-Bahillo, A ;

Fernández-Villalba, E ;

Navarro-Ruis, JM ;

Barreiro, AF ;

Poza, MPY ;

Herrero, MT .

NEUROENDOCRINOLOGY, 2003, 78 (02) :118-128

[4]

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo [J].

Barcia, Carlos ;

Maria Ros, Carmen ;

Annese, Valentina ;

Carrillo-de Sauvage, Maria Angeles ;

Ros-Bernal, Francisco ;

Gomez, Aurora ;

Enrique Yuste, Jose ;

Maria Campuzano, Carmen ;

de Pablos, Vicente ;

Fernandez-Villalba, Emiliano ;

Trinidad Herrero, Maria .

SCIENTIFIC REPORTS, 2012, 2

[5]

Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice model [J].

Czlonkowska, A ;

Kohutnicka, M ;

Kurkowska-Jastrzebska, I ;

Czlonkowski, A .

NEURODEGENERATION, 1996, 5 (02) :137-143

[6]

The substantia nigra of the human brain - II. Patterns of loss of dopamine-containing neurons in Parkinson's disease [J].

Damier, P ;

Hirsch, EC ;

Agid, Y ;

Graybiel, AM .

BRAIN, 1999, 122 :1437-1448

[7]

Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease [J].

Depboylu, Candan ;

Stricker, Sarah ;

Ghobril, Jean-Pierre ;

Oertel, Wolfgang H. ;

Priller, Josef ;

Hoeglinger, Guenter U. .

EXPERIMENTAL NEUROLOGY, 2012, 238 (02) :183-191

[8]

ANATOMY, PIGMENTATION, VENTRAL AND DORSAL SUBPOPULATIONS OF THE SUBSTANTIA-NIGRA, AND DIFFERENTIAL CELL-DEATH IN PARKINSONS-DISEASE [J].

GIBB, WRG ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1991, 54 (05) :388-396

[9]

STEREOLOGY OF ARBITRARY PARTICLES - A REVIEW OF UNBIASED NUMBER AND SIZE ESTIMATORS AND THE PRESENTATION OF SOME NEW ONES, IN MEMORY OF THOMPSON,WILLIAM,R. [J].

GUNDERSEN, HJG .

JOURNAL OF MICROSCOPY, 1986, 143 :3-45

[10]

DOES NEUROMELANIN CONTRIBUTE TO THE VULNERABILITY OF CATECHOLAMINERGIC NEURONS IN MONKEYS INTOXICATED WITH MPTP [J].

HERRERO, MT ;

HIRSCH, EC ;

KASTNER, A ;

RUBERG, M ;

LUQUIN, MR ;

LAGUNA, J ;

JAVOYAGID, F ;

OBESO, JA ;

AGID, Y .

NEUROSCIENCE, 1993, 56 (02) :499-511