Spontaneous Vesicle Formation of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymer

被引：31

作者：

Chen, Shu ^{[1
]}

Yang, Bin ^{[1
]}

Guo, Chen ^{[1
]}

Ma, Jun-He ^{[1
]}

Yang, Liang-Rong ^{[1
]}

Liang, Xiangfeng ^{[1
]}

Hua, Chao ^{[1
]}

Liu, Hui-Zhou ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Lab Separat Sci & Engn, Beijing 100080, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2008年 / 112卷 / 49期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

D O I：

10.1021/jp8019039

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A novel method has been developed to prepare vesicles from aqueous solutions of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, by adding anionic surfactant sodium dodecyl sulfate (SDS) and inorganic salt NaF. As determined by TEM and dynamic light scattering (DLS) measurements, the average diameter of vesicles is about 800 nm having 50 nm outer shell thickness. Identifying hydrophobic interactions between the block copolymers and the microenvironments around the vesicles using FTIR, H-1 NMR, and fluorescence spectroscopy techniques revealed the vesicle formation mechanism. The spontaneously formed vesicles were further cross-linked by converting the terminal hydroxyl groups of block copolymers into aldehydes, and then chemically bridging the polymer chains by the reaction between aldehydes and diamine compounds. The cross-linked vesicles are proved much more stable than free vesicles even at higher dilutions. The obtained vesicles with good stability and biocompatibility are promising candidates for widespread applications.

引用

页码：15659 / 15665

页数：7

共 52 条

[1] MICELLIZATION OF POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE) TRIBLOCK COPOLYMERS IN AQUEOUS-SOLUTIONS - THERMODYNAMICS OF COPOLYMER ASSOCIATION [J].