Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations

被引：53

作者：

Bruinink, Arie ^{[1
]}

Luginbuehl, Reto ^{[2
]}

机构：

[1] Empa Mat Sci & Technol, Lab Mat Biol Interact, CH-9014 St, Gallen, Switzerland

[2] RMS Fdn, CH-2544 Bettlach, Switzerland

来源：

TISSUE ENGINEERING III: CELL-SURFACE INTERACTIONS FOR TISSUE CULTURE | 2012年 / 126卷

关键词：

Biocompatibility; Limitations; Culture; In vivo; In vitro; Test battery; ISO10993; ASTM F748; Testing strategy; Cytotoxicity; Bioactivity; EMBRYONIC CHICK BRAIN; PROTEIN ADSORPTION; EXTRACELLULAR-MATRIX; CELL-ADHESION; STEM-CELLS; OSTEOBLASTIC DIFFERENTIATION; OXIDE NANOPARTICLES; OXIDATIVE STRESS; PRIMARY CULTURES; COLLAGEN MATRIX;

D O I：

10.1007/10_2011_111

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

The in vitro biocompatibility of novel materials has to be proven before a material can be used as component of a medical device. This must be done in cell culture tests according to internationally recognized standard protocols. Subsequently, preclinical and clinical tests must be performed to verify the safety of the new material and device. The present chapter focuses on the first step, the in vitro testing according to ISO 10993-5, and critically discusses its limited significance. Alternative strategies and a brief overview of activities to improve the current in vitro tests are presented in the concluding section.

引用

页码：117 / 152

页数：36

共 162 条

[1]

The competitive adsorption of human proteins onto natural-based biomaterials [J].

Alves, Catarina M. ;

Reis, Rui L. ;

Hunt, John A. .

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2010, 7 (50) :1367-1377

[2]

Biological responses to materials [J].

Anderson, JM .

ANNUAL REVIEW OF MATERIALS RESEARCH, 2001, 31 :81-110

[3]

[Anonymous], 1981, F719 ASTM INT

[4]

[Anonymous], 1981, F720 ASTM INT

[5]

[Anonymous], 2006, F748 ASTM INT

[6]

[Anonymous], 1984, F895 ASTM INT

[7]

Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers [J].

Arima, Yusuke ;

Iwata, Hiroo .

BIOMATERIALS, 2007, 28 (20) :3074-3082

[8]

ASTM, 2011, F04 MED SURG MAT DEV

[9]

STRUCTURE ACTIVITY RELATIONSHIP (SAR) MODELS ESTABLISHED INVITRO WITH THE NEUTRAL RED CYTOTOXICITY ASSAY [J].

BABICH, H ;

BORENFREUND, E .

TOXICOLOGY IN VITRO, 1987, 1 (01) :3-9

[10]

A novel in vitro exposure technique for toxicity testing of selected volatile organic compounds [J].

Bakand, S ;

Winder, C ;

Khalil, C ;

Hayes, A .

JOURNAL OF ENVIRONMENTAL MONITORING, 2006, 8 (01) :100-105

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