Synthesis and structure-activity relationship study of lamellarin derivatives

被引：93

作者：

Ishibashi, F

Tanabe, S

Oda, T

Iwao, M

机构：

[1] Nagasaki Univ, Div Marine Life Sci & Biochem, Fac Fisheries, Nagasaki 8528521, Japan

[2] Nagasaki Univ, Dept Appl Chem, Fac Engn, Nagasaki 8528521, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 04期

关键词：

D O I：

10.1021/np0104525

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten derivatives (3-12) of marine alkaloid lamellarin D (1) were synthesized and evaluated for cytotoxicity against a HeLa cell line in an effort to examine their structure-activity relationships. It appeared that the hydroxyl groups at positions C-8 and C-20 of 1 were important structural requirements for cytotoxic activity, while the hydroxyl group at C-14 and the two methoxy groups at C-13 and C-21 were not necessary for the activity.

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页码：500 / 504

页数：5

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