Renal urate transport

被引：80

作者：

Mount, David B.

Kwon, Charles Y.

Zandi-Nejad, Kambiz

机构：

[1] Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] VA Boston Healthcare Syst, Div Gen Internal Med, Boston, MA USA

[4] Childrens Hosp, Div Renal, Boston, MA 02115 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2006年 / 32卷 / 02期

关键词：

D O I：

10.1016/j.rdc.2006.02.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum uric acid is determined by a balance between production and renal excretion. Luminal reabsorption of urate by the proximal tubule from the glomerular ultrafiltrate involves coupling between sodium-anion cotransport and urate-anion exchange. Apical sodium-coupled cotransport of lactate, ketoacids, nicotinate, and pyrazinoate increases intracellular levels of these anions in proximal tubular cells, stimulating the apical absorption of luminal urate via anion exchange. Hyperuricemia occurs when plasma levels of these anions increase; for example, hyperuricemia is a well-recognized concomitant of lactic acidosis and ketoacidosis. Relevant developments in the molecular and renal physiology of urate homeostasis are reviewed.

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页码：313 / +

页数：20

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