Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties

被引：26

作者：

Braud, Emmanuelle ^{[1
,2
]}

Goddard, Mary-Lorene ^{[1
,2
]}

Kolb, Stephanie ^{[1
,2
]}

Brun, Marie-Priscille ^{[1
,2
]}

Mondesert, Odile ^{[3
]}

Quaranta, Muriel ^{[3
]}

Gresh, Nohad ^{[1
,2
]}

Ducommun, Bernard ^{[3
]}

Garbay, Christiane ^{[1
,2
]}

机构：

[1] Univ Paris 05, Lab Pharmacochim Mol & Cellulaire, UFR Biomed, F-75006 Paris, France

[2] INSERM, U648, F-75006 Paris, France

[3] Univ Toulouse 3, Lab Biol Cellulaire & Mol Controle Proliferat, IFR109, UMR 5088, F-31062 Toulouse, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 19期

关键词：

cancer; phosphatase CDC25; cell cycle regulation; quinone derivatives;

D O I：

10.1016/j.bmc.2008.08.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

CDC25 phosphatases are considered as attractive targets for anti-cancer therapy. To date, quinone derivatives are among the most potent inhibitors of CDC25 phosphatase activity. We present in this paper the synthesis and the biological evaluation of new quinolinedione and naphthoquinone derivatives, containing carboxylic or malonic acids groups introduced to mimic the role of the phosphate moieties of Cyclin-Dependent Kinase complexes. The most efficient compounds show inhibitory activity against CDC25B with IC(50) values in the 10 mu M range, and are cytotoxic against HeLa cells. (C) 2008 Published by Elsevier Ltd.

引用

收藏

页码：9040 / 9049

页数：10

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