Cytochrome P450-null mice

被引:29
作者
Buters, JTM [1 ]
Doehmer, J
Gonzalez, FJ
机构
[1] Tech Univ Munich, Inst Toxicol & Environm Hlth, D-80636 Munich, Germany
[2] NCI, Metab Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA
关键词
null mice; cytochrome P450; CYP1A1; CYP1A2; CYP1B1; CYP2E1; caffeine; acetaminophen; dimethylbenzo[a]anthracene;
D O I
10.1081/DMR-100101929
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:437 / 447
页数:11
相关论文
共 32 条
[1]   HUMAN CDNA-EXPRESSED CYTOCHROME-P450 IA2 - MUTAGEN ACTIVATION AND SUBSTRATE-SPECIFICITY [J].
AOYAMA, T ;
GONZALEZ, FJ ;
GELBOIN, HV .
MOLECULAR CARCINOGENESIS, 1989, 2 (04) :192-198
[2]   Role of CYP1A2 in caffeine pharmacokinetics and metabolism: Studies using mice deficient in CYP1A2 [J].
Buters, JTM ;
Tang, BK ;
Pineau, T ;
Gelboin, HV ;
Kimura, S ;
Gonzalez, FJ .
PHARMACOGENETICS, 1996, 6 (04) :291-296
[3]  
CASAZZA JP, 1984, J BIOL CHEM, V259, P231
[4]   ROLE OF CYTOCHROME P4501A2 IN CHEMICAL CARCINOGENESIS - IMPLICATIONS FOR HUMAN VARIABILITY IN EXPRESSION AND ENZYME-ACTIVITY [J].
EATON, DL ;
GALLAGHER, EP ;
BAMMLER, TK ;
KUNZE, KL .
PHARMACOGENETICS, 1995, 5 (05) :259-274
[5]   CONTRIBUTION OF CYP1A1, AND CYP1A2 TO THE ACTIVATION OF HETEROCYCLIC AMINES IN MONKEYS AND HUMAN [J].
EDWARDS, RJ ;
MURRAY, BP ;
MURRAY, S ;
SCHULZ, T ;
NEUBERT, D ;
GANT, TW ;
THORGEIRSSON, SS ;
BOOBIS, AR ;
DAVIES, DS .
CARCINOGENESIS, 1994, 15 (05) :829-836
[6]   IMMUNE-SYSTEM IMPAIRMENT AND HEPATIC-FIBROSIS IN MICE LACKING THE DIOXIN-BINDING AH RECEPTOR [J].
FERNANDEZSALGUERO, P ;
PINEAU, T ;
HILBERT, DM ;
MCPHAIL, T ;
LEE, SST ;
KIMURA, S ;
NEBERT, DW ;
RUDIKOFF, S ;
WARD, JM ;
GONZALEZ, FJ .
SCIENCE, 1995, 268 (5211) :722-726
[7]   Lesions of aryl-hydrocarbon receptor-deficient mice [J].
FernandezSalguero, PM ;
Ward, JM ;
Sundberg, JP ;
Gonzalez, FJ .
VETERINARY PATHOLOGY, 1997, 34 (06) :605-614
[8]   EVOLUTION OF THE P450-GENE SUPERFAMILY - ANIMAL PLANT WARFARE, MOLECULAR DRIVE AND HUMAN GENETIC-DIFFERENCES IN DRUG OXIDATION [J].
GONZALEZ, FJ ;
NEBERT, DW .
TRENDS IN GENETICS, 1990, 6 (06) :182-186
[9]  
GONZALEZ FJ, 1996, CYTOCHROMES P450 MET, P183
[10]   ROLE OF HUMAN CYTOCHROME-P-450-IIE1 IN THE OXIDATION OF MANY LOW-MOLECULAR-WEIGHT CANCER SUSPECTS [J].
GUENGERICH, FP ;
KIM, DH ;
IWASAKI, M .
CHEMICAL RESEARCH IN TOXICOLOGY, 1991, 4 (02) :168-179