The Effects of Monosodium Glutamate and Tannic Acid on Adult Rats

被引:27
作者
Calis, Ibrahim Ugur [1 ]
Cosan, Didem Turgut [1 ]
Saydam, Faruk [2 ]
Kolac, Umut Kerem [1 ]
Soyocak, Ahu [3 ]
Kurt, Hulyam [1 ]
Gunes, Hasan Veysi [1 ]
Sahinturk, Varol [4 ]
Mutlu, Fezan Sahin [5 ]
Koroglu, Zeynep Ozdemir [6 ]
Degirmenci, Irfan [1 ]
机构
[1] Eskisehir Osmangazi Univ, Dept Med Biol, Fac Med, Eskisehir, Turkey
[2] Recep Tayyip Erdogan Univ, Dept Med Biol, Fac Med, Rize, Turkey
[3] Istanbul Aydin Univ, Dept Med Biol, Fac Med, Istanbul, Turkey
[4] Eskisehir Osmangazi Univ, Dept Histol & Embryol, Fac Med, Eskisehir, Turkey
[5] Eskisehir Osmangazi Univ, Dept Biostat, Fac Med, Eskisehir, Turkey
[6] Eskisehir Osmangazi Univ, Vocat Sch Hlth Serv, Eskisehir, Turkey
关键词
Monosodium Glutamate; Oxidative Stress; Antioxidant; Tannic Acid; INDUCED OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; FLOWERS; DAMAGE; LEAD;
D O I
10.5812/ircmj.37912
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Background: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. The excessive use of MSG has been shown to increase oxidative stress in different organ systems and causes glucose metabolism disorders, obesity, and coronary diseases. Objectives: In this study, the antioxidant activity of tannic acid was investigated experimentally with respect to its protective effects against overdosed MSG-induced oxidative stress in rats. The study took place in Turkey in August 2013. Methods: Four groups (n = 7) of three-to four-month-old Sprague-Dawley female rats were used in this study. The first group was the control, who were administered saline. The second group received tannic acid (50 mg/kg, 3 days) intraperitoneally (i.p.). The third group received MSG (2 g/kg, 7 days) i.p., and the fourth group received both tannic acid (50 mg/kg, 3 days, pretreatment) and MSG (2 g/kg, 7 days) i.p. The animals were euthanized ten days later. Blood was collected for determining the hematological values and blood glucose levels. Superoxide dismutase (SOD) andmalondialdehyde(MDA) levels were determined in the brain, liver, and kidney homogenates, and in the erythrocyte hemolysate. Histopathological examination of the brain, liver, and kidneys was conducted through hematoxylin-eosin staining. Results: The data showed that the tannic acid treatment statistically decreased the MDA levels in the brain tissues of the group administered MSG and tannic acid (P < 0.001) when compared to the corresponding values of the control group. The SOD activities in the blood hemolysates of the MSGandtannic acid group increased when compared to the corresponding values for the MSGgroup (P < 0.01). Additionally, we found that pretreatment with tannic acid reduced blood glucose levels in comparison to the levels of the MSG group (P = 0.029). The results of our study show that tannic acid pretreatment in adult rats decreased blood glucose levels and oxidative stress. Conclusions: In the literature, it was observed that short-term MSG exposure does not cause significant histological changes in the kidneys, liver, or brain cortex. These findings should be re-evaluated in additional long-term studies.
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页数:7
相关论文
共 27 条
[1]
Bhattacharya T, 2011, Nepal Med Coll J, V13, P11
[2]
Very rapid quantification of malondialdehyde (MDA) in rat brain exposed to lead, aluminium and phenolic antioxidants by high-performance liquid chromatography-fluorescence detection [J].
Candan, N. ;
Tuzmen, N. .
NEUROTOXICOLOGY, 2008, 29 (04) :708-713
[3]
Impact of tannic acid on blood pressure, oxidative stress and urinary parameters in L-NNA-induced hypertensive rats [J].
Cosan, Didem Turgut ;
Saydam, Faruk ;
Ozbayer, Cansu ;
Doganer, Fulya ;
Soyocak, Ahu ;
Gunes, Hasan Veysi ;
Degirmenci, Irfan ;
Kurt, Hulyam ;
Ustuner, Mehmet Cengiz ;
Bal, Cengiz .
CYTOTECHNOLOGY, 2015, 67 (01) :97-105
[4]
A review of the health effects of green tea catechins in in vivo animal models [J].
Crespy, V ;
Williamson, G .
JOURNAL OF NUTRITION, 2004, 134 (12) :3431S-3440S
[5]
Diplock A, 1998, HEALTY LIFESTYLES NU, P16
[6]
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice [J].
El-Sayed, IH ;
Lotfy, M ;
El-Khawaga, OAY ;
Nasif, WA ;
El-Shahat, M .
TOXICOLOGY AND INDUSTRIAL HEALTH, 2006, 22 (04) :157-163
[7]
Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin [J].
Farombi, EO ;
Onyema, OO .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2006, 25 (05) :251-259
[8]
Radical scavenging and antioxidant activity of tannic acid [J].
Gulcin, Ilhami ;
Huyut, Zubeyr ;
Elmastas, Mahfuz ;
Aboul-Enein, Hassan Y. .
ARABIAN JOURNAL OF CHEMISTRY, 2010, 3 (01) :43-53
[9]
Islam Md Shahidul, 2012, Methods Mol Biol, V933, P161, DOI 10.1007/978-1-62703-068-7_10
[10]
Antioxidants in fruits and vegetables - the millennium's health [J].
Kaur, C ;
Kapoor, HC .
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2001, 36 (07) :703-725