Attachable Solvatochromic Fluorophores and Bioconjugation Studies

被引：35

作者：

Benedetti, Erica ^{[1
]}

Veliz, Andrea B. E. ^{[1
]}

Charpenay, Melanie ^{[1
]}

Kocsis, Laura S. ^{[1
]}

Brummond, Kay M. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 11期

基金：

美国国家科学基金会;

关键词：

SINGLE-MOLECULE PROBES; PHOTOPHYSICAL PROPERTIES; SPECTRAL PROPERTIES; FLUORESCENT-PROBE; C-LAURDAN; PRODAN; SPECTROSCOPY; MEMBRANES; PROTEINS; MODELS;

D O I：

10.1021/ol400292q

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

The synthesis and utility of attachable cyclopenta[b]naphthalene solvatochromic fluorophores related to Prodan are described. Two fluorophores were selected for functionalization and bioconjugation studies. The skeletons were chemically modified to include reactive functional groups and showed minimal alteration of the optical properties when compared to the parent dyes. The functionalized fluorophores were covalently attached to the carboxyl group of a fatty acid, and azido- and thiol-containing amino acids, demonstrating their potential for labeling biomolecules.

引用

收藏

页码：2578 / 2581

页数：4

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