T cells orchestrate intestinal mucosal shape and integrity

被引：99

作者：

MacDonald, TT ^{[1
]}

Bajaj-Elliott, M ^{[1
]}

Pender, SLF ^{[1
]}

机构：

[1] St Bartholomews Hosp, Dept Paediat Gastroenterol, St Bartholomews & Royal London Sch Med & Dent, London EC1A 7BE, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 11期

关键词：

D O I：

10.1016/S0167-5699(99)01536-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper I-type immune reactions in the gut cause important human diseases, such as Crohn's disease and coeliac disease. Here, Tom MacDonald, Mona Elliott and Sylvia Pender suggest that the tissue injury in these diseases is mediated not by the immune cells, but by cytokine-induced changes in keratinocyte growth fact or and matrix metalloproteinase production by resident gut myofibroblasts.

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页码：505 / 510

页数：6

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