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IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
被引:512
作者:

Vieira, PL
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机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

Christensen, JR
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机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

Minaee, S
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机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

O'Neill, EJ
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机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

Barrat, FJ
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h-index: 0
机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

Boonstra, A
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h-index: 0
机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

Barthlott, T
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机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

Stockinger, B
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机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

Wraith, DC
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机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England

O'Garra, A
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h-index: 0
机构: Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England
机构:
[1] Natl Inst Med Res, Div Immunoregulat, London NW7 1AA, England
[2] Natl Inst Med Res, Div Mol Immunol, London NW7 1AA, England
[3] Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon, England
[4] Dynavax Technol, Berkeley, CA 94710 USA
关键词:
D O I:
10.4049/jimmunol.172.10.5986
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Regulatory T cells (T-Reg) control immune responses to self and nonself Ags. The relationship between Ag-driven IL-10-secreting T-Reg (IL-10-T-Reg) and naturally occurring CD4(+)CD25(+) T-Reg is as yet unclear. We show that mouse IL-10-T-Reg obtained using either in vitro or in vivo regimens of antigenic stimulation did not express the CD4(+)CD25(+) T-Reg-associated transcription factor Foxp3. However, despite the absence of Foxp3 expression,, homogeneous populations of IL-10-T-Reg inhibited the in vitro proliferation of CD4(+)CD25(-) T cells with a similar efficiency to that of CD4(+)CD25(+) T-Reg. This inhibition of T cell proliferation by IL-10-T-Reg was achieved through an IL-10-independent mechanism as seen for CD4(+)CD25(+)T(Reg) and was overcome by exogenous IL-2. Both IL-10-T-Reg and CD4(+)CD25(+) T-Reg were similar in that they produced little to no IL-2. These data show that Foxp3 expression is not a prerequisite for IL-10-T-Reg activity in vitro or in vivo, and suggest that IL-10-T-Reg and naturally occurring CD4(+)CD25(+) T-Reg may have distinct origins.
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页码:5986 / 5993
页数:8
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