Tissue-specific transcription pattern of the adenine nucleotide translocase isoforms in humans

被引：101

作者：

Doerner, A

Pauschinger, M

Badorff, A

Noutsias, M

Giessen, S

Schulze, K

Bilger, J

Rauch, U

Schultheiss, HP

机构：

[1] Department of Cardiology, Benjamin Franklin Hospital, Free University of Berlin, 12200 Berlin

来源：

FEBS LETTERS | 1997年 / 414卷 / 02期

关键词：

adenine nucleotide translocator; isoform; tissue differentiation;

D O I：

10.1016/S0014-5793(97)01000-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three adenine nucleotide translocase isoforms (ANT1, ANT2 and ANT3) are coded by different genes, The relative amounts of the three ANT isoform mRNAs were determined in detail in various human tissues, ANT isoforms were co-expressed in all tested tissues revealing tissue-specific transcription patterns, The highest ANT1 mRNA proportions were found in terminally differentiated tissues like skeletal muscle, heart anal brain, whereas ANT2 was mainly expressed in tissues capable of proliferation and regeneration as in the kidneys, spleen, liver, fibroblasts and lymphocytes, The ANT3 mRNA proportion was not prominently expressed in any of the tissues tested, In conclusion, tissue-specific expression of ANT isoforms is strongly related to the state of cellular differentiation. (C) 1997 Federation of European Biochemical Societies.

引用

页码：258 / 262

页数：5

共 21 条

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