Durability of the effects of cognitive-behavioural therapy in the treatment of chronic schizophrenia: 12-month follow-up

Background Persistent drug-resistant psychotic symptoms are a pervasive problem in the treatment of schizophrenia. Aims To evaluate the durability of the treatment effects of cognitive behavioural therapy for chronic schizophrenia one year after treatment termination. Method A comparison of clinical outcomes was made at one-year follow-up from a randomised trial of cognitive behavioural therapy, supportive counselling and routine care alone in the treatment-of chronic schizophrenia. Results Seventy out of the 72 patients (97%) who completed treatment were assessed at follow-up. There were significant differences between the three groups when positive and negative symptoms were analysed by means of ANCOVAs. Between-group comparisons indicated significant differences between cognitive-behavioural therapy and routine care at follow-up for positive symptoms. There was a trend towards significance for both cognitive - behavioural therapy and supportive counselling to be superior to routine care alone on negative symptoms. Conclusions At 12-month follow-up the significant advantage of cognitive behavioural therapy compared to routine care alone remained. Declaration of interest The research was supported by a project grant from The Wellcome Trust.